Telomere maintenance and DNA repair are crucial processes that protect the genome against instability. RTEL1, an essential iron-sulfur cluster-containing helicase, is a dominant factor that controls telomere length in mice and is required for telomere integrity. In addition, RTEL1 promotes synthesis-dependent strand annealing to direct DNA double-strand breaks into non-crossover outcomes during...

The accurate maintenance of mitochondrial DNA (mtDNA) is required in order for eukaryotic cells to assemble a functional electron transport chain. This independently-maintained genome relies on nuclear-encoded proteins that are imported into the mitochondria to carry out replication and repair processes. Decades of research has made clear that mitochondria employ robust and varied mtDNA repair ...

Building maintenance management involves decision-making under multiple objectives and uncertainty, in addition to budgetary constraints. This paper presents the development of a multiobjective and stochastic optimization system for maintenance management of roofing systems that integrates stochastic condition assessment and performance prediction models with a multiobjective optimization appro...

The current conditions of Russian territories road infrastructure, regional budgetary funding, differences in economic potential and the economy structure constituent entities Federation determine relevance development improvement regulatory base. This is important field tariff policy, one elements which approval basic standards rules for calculating amount funds capital repairs, repairs mainte...

Genome-scale screening studies are gradually accumulating a wealth of data on the putative involvement of hundreds of genes/proteins in various cellular responses or functions. A fundamental challenge is to chart out the protein pathways that underlie these systems. Previous approaches to the problem have either employed a local optimization criterion, aiming to infer each pathway independently...

The high reliability of modern engineering systems is achieved by performing predictive maintenance. Mathematical models based on stochastic timed colored Petri nets are an effective tool for developing complex production processes Industry 4.0. This article discusses the maintainability evaluation used in hierarchical net models. simulation model was built using nets, and constructed with four...