A study of respiration and glycolysis in vitro of retinal pigment epithelium and retina minus the pigment epithelial layer has indicated metabolic similarities and differences between the two tissues. Aerobic lactic acid production from glucose was one-half in pigment epithelium what it was in retina, and the Pasteur effect operated with approximately the same efficiency in either tissue. Pigme...

A study of respiration and glycolysis in vitro of retinal pigment epithelium and retina minus the pigment epithelial layer has indicated metabolic similarities and differences between the two tissues. Aerobic lactic acid production from glucose was one-half in pigment epithelium what it was in retina, and the Pasteur effect operated with approximately the same efficiency in either tissue. Pigme...

PURPOSE Dietary supplementation with vitamin A is sometimes prescribed as a treatment for retinitis pigmentosa, a group of inherited retinal degenerations that cause progressive blindness. Loss-of-function mutations in the ABCA4 gene are responsible for a subset of recessive retinitis pigmentosa. Other mutant alleles of ABCA4 cause the related diseases, recessive cone-rod dystrophy, and recessi...

Although both 11-cis and all-tmns retinyl esters exist in the retinal pigment epithelium, the relative importance of each in the visual cycle has been unclear. Recent data indicate that there are 2 biochemical pathways leading to the formation of 11-cis retinoids from the retinal pigment epithelium pool of retinyl esters. One well-established pathway is located in the endoplasmic reticulum wher...

Macular edema has been observed frequently in man after cataract extraction, but pathogenic mechanisms remain unclear. Seven eyes of four young adult rhesus monkeys underwent lens extraction. The retinas and maculae of these eyes were examined by ophthalmoscopy fundus photography, fluorescein angiography, light and electron microscopy, and the horseradish peroxidase tracer technique. In the mac...

Exudative retinal detachment occurs when fluid accumulates between the neurosensory retina and pigment epithelium. Ocular diseases or multisystem conditions such as nephrotic syndrome may lead to exudative detachment. This report describes a case of secondary minimal change disease, anasarca bilateral serous macular in an adult patient. A 75-year-old male patient presented emergency department ...