purpose: true neoplasm (adenocarcinoma) of retinal pigment epithelium (rpe) is very rare since it can be misdiagnosed as intraocular malignant melanoma it is of importance to know the clinical and pathologic aspects of this neoplasm. here, we report a case of adenocarcinoma of rpe. methods: case report. results: a 60-year-old man with progressive loss of the vision of the right eye was enucleat...

aim: to report a patient with fundus flavimaculatus or macular dystrophy with flecks, who came to medical attention due to deteriorated vision in one eye and combined hamartoma of the retina and retinal pigment epithelium. case presentation: a 26 year old lady was referred with history of progressive decreased vision in both eyes since childhood with recently deteriorated vision in her right ey...

Several signaling pathways and transcription factors control the cell fate in its in vitro development and differentiation. The orchestrated use of these factors results in cell specification. In coculture methods, many of these factors secrete from host cells but control the process. Today, transcription factors required for retinal progenitor cells are well known, but the generation of these ...

The retinal pigment epithelium located between the neurosensory retina and the choroidal vasculature is critical for the function and maintenance of both the photoreceptors and underlying capillary endothelium. While the trophic role of retinal pigment epithelium on choroidal endothelial cells is well recognized, the existence of a reciprocal regulatory function of endothelial cells on retinal ...

The retinal pigment epithelium is an important part of the vertebrate eye, particularly in studying the causes and possible treatment of age-related macular degeneration. The retinal pigment epithelium is difficult to access in vivo due to its location at the back of the eye, making experimentation with age-related macular degeneration treatments problematic. An alternative to in vivo experimen...

PURPOSE To investigate the possible role of zinc-metallothionein in human retinal pigment epithelium with regard to age-related changes. METHODS A cadmium/heme assay was used to quantitate metallothionein in isolated macular and peripheral retinal pigment epithelium from donors ranging in age from 28 to 91 yr (n = 16, mean age = 68.6 yr). RESULTS It was found that peripheral retinal pigment...

objective: human retinal pigment epithelium (hrpe) is a cell monolayer located in the outer part of the retina that is in contact with photoreceptors. in many diseases rpe cells damage. one way for treating this disease is the implantation of intact instead of damaged cells. for this reason different types of substrates have been used for cell cultivation. this study has used alginate and a ble...

Muscarinic receptors are the predominant cholinergic receptors in the central and peripheral nervous systems. Recently, activation of muscarinic receptors was found to elicit pigment granule dispersion in retinal pigment epithelium isolated from bluegill fish. Pigment granule movement in retinal pigment epithelium is a light-adaptive mechanism in fish. In the present study, we used pharmacologi...