OBJECTIVES To verify the accuracy of prospective memory (ProM) tests in Alzheimer's disease (AD). METHODS Twenty mild AD patients (CDR 1), and 20 controls underwent Digit Span (DS), Trail Making (TM) A and B, visual perception, Rey Auditory-Verbal Learning tests, and Cornell Scale for Depression. AD diagnosis was based on DSM-IV and NINCDS-ADRDA criteria. ProM was assessed with the appointmen...

This study modeled predementia Alzheimer's disease clinical trials. Longitudinal data from cognitively normal (CN) and mild cognitive impairment (MCI) participants in the Alzheimer's Disease Neuroimaging Initiative were used to calculate sample size requirements for trials using outcome measures, including the Clinical Dementia Rating scale sum of boxes, Mini-Mental State Examination, Alzheimer...

BACKGROUND Levodopa-associated motor fluctuations are common complications observed in Parkinson's disease (PD) patients. Although nonmotor fluctuations are a significant cause of morbidity, they frequently are not properly identified. Few studies have characterized the nonmotor emotional fluctuations and their relation to motor fluctuations. AIMS The objective of the present study is to anal...

A battery of neuropsychological tests (e.g., Wisconsin Card Sorting Test, Trail Making Test, Rey Auditory-Verbal Learning Test, Wechsler Adult Intelligence Scale--Revised Block Design, Object Assembly, and Digit Symbol tests) was administered to 259 adults ages 18 to 94 who reported themselves to be in good to excellent health. Moderate age-related declines were apparent in performance measures...

An issue that often confronts the clinician referred an elderly person for neuropsychological assessment is how to interpret the significance of changes in test scores over time. In this report, data useful for estimating the statistical significance of changes on the Rey Auditory Verbal Learning Test (AVLT) are presented. The sample tested comprised 253 healthy persons aged 65 and over taking ...

BACKGROUND 3,4-methylenedioxymethamphetamine (MDMA or "Ecstasy") is known to damage brain serotonin neurons in animals and possibly humans. Because serotonergic damage may adversely affect memory, we compared verbal memory function between MDMA users and MDMA-naïve control subjects and evaluated the relationship between verbal memory function and neuronal dysfunction in the MDMA users. METHOD...

Williams syndrome (WS) is a neurodevelopmental genetic disorder often described as being characterized by a dissociative cognitive architecture, in which profound impairments of visuo-spatial cognition contrast with relative preservation of linguistic, face recognition and auditory short-memory abilities. This asymmetric and dissociative cognition has been also proposed to characterize WS memor...

OBJECTIVE The objective of this study was to investigate the effectiveness of Bacopa monnieri Linn. for improvement of memory performance in healthy older persons. STUDY DESIGN This was a randomized, double-blind, placebo-controlled trial. SETTING AND PARTICIPANTS The trial took place in Lismore, NSW, Australia between February and July 2005. Ninety-eight (98) healthy participants over 55 y...

Memory loss after brain injury can be a source of considerable morbidity, but there are presently few therapeutic options for restoring memory function. We have previously demonstrated that burst stimulation of the fornix is able to significantly improve memory in a rodent model of traumatic brain injury. The present study is a preliminary investigation with a small group of cases to explore wh...