Recently direct-acting antiviral agents, such as hepatitis C virus (HCV) non-structural 3/4A (NS3/4A) protease inhibitors (PI), have been introduced, and triple therapy regimens that include PI with conventional pegylated interferon α and ribavirin have significantly improved the sustained virological response (SVR) rate, up to 80% for both treatment-naïve and treatment-experienced patients wit...

Hypoxia-inducible factor (HIF), which plays a crucial role in oxygen homeostasis, contributes to immunosuppression, tumor angiogenesis, multidrug resistance, photodynamic therapy and metastasis. HIF as therapeutic target has attracted scientists’ strong academic research interests. Short interfering RNA (siRNA) antisense oligonucleotide (ASO) are the more promising broadly utilized methods for ...

Abstract With the rapid development of biotechnologies and deep improvement knowledge, “Discovery” is initial period source innovation clinical translational medicine. The international journal Clinical Translational Discovery serves to highlight unknown or unclear aspects medicine‐associated technologies, mechanisms, therapies ( https://onlinelibrary.wiley.com/journal/27680622 ). aims define i...

OBJECTIVES Hepatitis C-virus-persistence after orthotopic liver transplant leads to reduced patient and graft survival compared to other indications. Current interferon-based antiviral therapy of hepatitis C-virus-infection posttransplant provides a sustained response rate of 30% to 40%. This study, performed in an hepatitis C-virus-reinfected liver transplant population, examines the antiviral...

post-integration steps, inhibit/inactivate progeny virus RNA packaging and/or reverse transcription, and use HIV for anti-HIV gene transfer during the subsequent round of infection 3.5.1. Ribozymes 4. Current anti-HIV gene therapy clinical trials using interfering RNA-based strategies 4.1. Antisense RNAs 4.2. Sense RNAs 4.3. Ribozymes 5. Conclusions and future prospects 6. Acknowledgements 7. R...

Currently, the daily routine of a molecular pathologist is DNA methylation and RNA sequencing. The authors, from standpoint researchers clinicians, explain methods used not only to diagnose brain tumors, but also search for possible targets therapy.