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The objective of this study was to propose a suitable electrode disposition and shape for iontophoretic drug delivery systems in consideration of a reduction in skin barrier function and a distribution of current density. The reduction in barrier function was evaluated with our proposed method, which measured the resistance in the short term. The distribution was estimated using an electromagne...

The human immunodeficiency virus type 2 (HIV-2) strain ROD/B can efficiently use the 7tm chemokine receptor CXCR-4 as a primary receptor to enter CD4-negative cells. We have stably expressed CXCR-4 on mink lung Mv-1-lu and feline kidney CCC cells (normally restrictive to HIV entry) and have shown efficient fusion, entry, and replication of ROD/B. Mutation of the two N-linked glycosylation sites...

The manipulation of individual micrometer sized objects has been the focus of significant research efforts over the last few years. A previously proposed method for the arbitrary manipulation of nanoparticles is experimentally demonstrated. This method employs dielectrophoretic forces for the planar control of the motion and orientation of such nanoparticles between a set of microfabricated ele...

We previously reported that supplementation with 17beta-estradiol (E2) attenuates albuminuria, glomerulosclerosis, and tubulointerstitial fibrosis in diabetic nephropathy. The present study examined the mechanisms by which E2 regulates extracellular matrix (ECM) metabolism, a process that contributes to the development of glomerulosclerosis and tubulointerstitial fibrosis. The study was perform...

The manipulation of individual submicron-sized objects has been the focus of significant efforts over the last few years. A method to arbitrarily move and orient a set of rod-shaped conductive particles in a region defined by a set of electrodes using positive dielectrophoretic forces is presented. While the orientation of each particle is directly specified through the angle of the local elect...

Three types of compensation electrode are analyzed, which give a more linear phase shift to the propagating optical beam for the planar electrooptic prism deflector. For Types I and III, the more linear phase shift is achieved by varying the slope of the central tilt electrode at the edge regions. For Type II, the more linear phase shift is achieved by cascading an electrode, giving an opposite...

Nonconvulsive status epilepticus (NCSE) has rapidly expanded from classical features such as staring, repetitive blinking, chewing, swallowing, and automatism to include coma, prolonged apnea, cardiac arrest, dementia, and higher brain dysfunction, which were demonstrated mainly after the 2000s by us and other groups. This review details novel clinical features of NCSE as a manifestation of epi...

This review first describes the invention of functional interfaces to promote biochemical redox reactions between substrates in dipolar aprotic solvents and enzymes or related compounds immobilized at the interface. The interfaces contain hydrophilic polymer membranes, a gold nanoparticle self-assembled electrode constructed by using rigid rod dithiols, and binary self-assembled monolayers comp...