BACKGROUND In low resource settings, Salmonella serovars frequently cause bloodstream infections. This study investigated the diagnostic performance of immunochromatographic rapid diagnostic tests (RDTs), which detect Salmonella antigens, when applied to stored grown blood culture broth. MATERIAL/METHODS The SD Bioline One Step Salmonella Typhi Ag Rapid Detection Kit (Standard Diagnostics, Re...

Live Salmonella typhi administered intraperitoneally, acetone-killed S. typhi administered intraperitoneally, and live S. typhi given orally, with their effectiveness decreasing in that order, protected Swiss white mice against death from challenge with a virulent Salmonella typhimurium hybrid expressing S. typhi antigens.

This study was carried out to assess the antimicrobial activities of Sphenocentrum jollyanum and Mangifera indica extract on Salmonella typhi. The antimicrobial activities of these plant extract <50% ethanol was tested against Salmonella typhi mostly belongs to pathogenic bacteria, by agar well diffusion method. The crude extracts showed a broad extract spectrum of an antibacterial activity inh...

OBJECTIVES Decreased susceptibility to fluoroquinolones has become a major problem for the successful therapy of human infections caused by Salmonella enterica, especially the life-threatening typhoid and paratyphoid fevers. METHODS By using Luminex xTAG beads, we developed a rapid, reliable and cost-effective multiplexed genotyping assay for simultaneously detecting 11 mutations in gyrA, gyr...

The immunogenicity of a single dose of Salmonella typhi(S.typhi) Vi capsular polysaccharide(CPS) vaccine was evaluated before, and at 1, 3, 12, and 36 months after vaccination. Eighty-five adults(20-28 years of age) and sixty-four children(8-16 years of age) received a single dose of 25 micrograms Vi CPS vaccine intramuscularly, and antibody titers to Vi CPS were measured by passive hemagglutin...

Background and Objective: Salmonella typhi is one of the major challenges for the human and animal health. Salmonella with high pathogenicity can be harmful factor for human health. The control of this pathogen is a big challenge as it can cause serious infectious diseases such as gastroenteritis, septicemia and typhoid fever. On the other side, there are many factors such as toxin-antitoxin (T...

Unlike broad-host Salmonella serovars, which cause self-limiting disease, Salmonella enterica serovar Typhi can infect only humans causing typhoid fever, a life-threatening systemic disease. The molecular bases for these differences are presently unknown. Here we show that the GTPase Rab29 (Rab7L1) distinguishes the intracellular vacuole of human-adapted and broad-host Salmonella serovars. A sc...