HIV integrase has emerged as a promising target for discovery of agents against the acquired immunodeficiency syndrome (AIDS) pandemic. With the purpose of designing new chemotypes with enhanced potencies against the HIV integrase enzyme, the QSAR study carried out on 37 novel phthalimide derivatives is presented. The developed QSAR model was validated by standard statistical parameters and thr...

Introduction Diffusion Tensor Imaging (DTI) has been proposed to visualize the fibres of brain white matter (WM) based on the selectivity of the maximal apparent diffusion coefficient (ADC) which correspond to the water diffusion along the axons. DTI potentially provides more detailed information about tissue organization but significant questions remain concerning different relations between t...

Arsenate and nitrate can be removed quantitatively from drinking water by anion exchange. However, if the raw water contains substantial concentrations of sulfate or nitrate, the resin becomes exhausted quickly, and the requirements for regenerant (brine) can make the process unattractive. Previously, we described a modified ion exchange operating procedure for arsenic removal from solutions co...

When an object is illuminated, it will absorb radiation proportionally to its absorption coefficient: Darker portions of the object will absorb more light than more transparent ones. Is there a way around this? In this paper we analyze a setup which uses classical light sources (i.e. coherent beams) and permits to easily tune the quantity of a light absorbed by an object independently on its tr...

In this study, we analyze the effects of membrane properties, namely water permeability, solute permeability, and structural parameter, on the overall performance of an FO membrane module to extract water from simulated seawater (0.6 M NaCl). By considering the thermodynamic limit of operation, we demonstrate that the maximum achievable water recovery is practically independent of membrane prop...

A theoretical model was developed to relate the size selectivity of the glomerular barrier to the structural characteristics of the individual layers of the capillary wall. Thicknesses and other linear dimensions were evaluated, where possible, from previous electron microscopic studies. The glomerular basement membrane (GBM) was represented as a homogeneous material characterized by a Darcy pe...

A wide range of homogeneous elastomeric membranes has been prepared using dicumylperoxide as a general cross-linking agent. The membranes have been used for both equilibrium sorption measurements and steady-state pervaporation experiments to study solution-diffusion phenomena in the removal of volatile organic components from aqueous solutions. Pervaporation experiments have been performed unde...

Chromatography coupling to mass spectrometry becomes a vital instrumentation tool for the separation and determination of small molecules qualitatively and quantitatively. In this study, the author is focused on the mitragynine and 7hydroxymitragynine. Mitragynine and its major metabolite, 7-hydroxymitragynine (also known as “kratom”), are drugs which extracted from a tree planted in Thailand, ...