A new series of 4-chloro-N-(2-(substitutedphenyl)-4-oxothiazolidin-3-yl)-2-phenoxybenzamide derivatives were designed, synthesized and biologically evaluated as anticonvulsant agents. The designed compounds have the main essential functional groups for binding to the benzodiazepine receptors and 4-thiazolidinone ring as an anticonvulsant pharmacophore. Some of the new synthesized compounds show...

BACKGROUND The market of hypnotic and sedative drugs is being updated due to the high toxicity barbiturates limitations their use. Currently, safer such as Z-drugs, Doxylamine, some benzodiazepine derivatives are often prescribed for treatment anxiety insomnia, but they can cause acute poisoning if overdosed or in case nonmedical AIM To establish an affordable express thin-layer chromatography ...

INTRODUCTION Insomnia is a condition that affects nearly everyone at some point in life. Up to 40% of American adults have intermittent insomnia, and 10% to 15% have a chronic sleep problem.1 The main presentation of insomnia is difficulty with either falling asleep or maintaining sleep throughout the night. Complaints of insomnia tend to increase with age. Elderly people report trouble falling...

A series of 4 – aryl substituted semicarbazones of some terpenes ie , citral ( acyclic terpene ) , camphor ( bicyclic terpene ) and menthone ( monocyclic terpene ) were synthesized from substituted anilines , to meet the structural requirements essential for anticonvulsant activity . The structures of the synthesized terpene semicarbazones were confirmed by I.R. , H-NMR and elemental analysis. ...

BACKGROUND Alcohol withdrawal delirium is the most serious manifestation of alcohol withdrawal. Evidence suggests that appropriate care improves mortality, but systematic reviews are unavailable. METHODS Articles with original data on management of alcohol withdrawal delirium underwent structured review and meta-analysis. RESULTS Meta-analysis of 9 prospective controlled trials demonstrated...

Ziziphus nummularia from Rhamnaceae family is traditionally used for sedative-hypnotic, antipyretic and analgesic purposes; however, scientific validations are lacking. This in vivo study was undertaken to verify the above ameliorative properties of Z. nummularia root methanolic extract. Various fractions of the extract were assayed on Balb/c mice by open field, Brewer's yeast-induced hyperther...

This review focuses on the unique clinical and molecular pharmacologic features of etomidate. Among general anesthesia induction drugs, etomidate is the only imidazole, and it has the most favorable therapeutic index for single-bolus administration. It also produces a unique toxicity among anesthetic drugs: inhibition of adrenal steroid synthesis that far outlasts its hypnotic action and that m...