Mutations in the gap junction β2 (GJB2) gene, encoding the connexin26 (CX26) protein, are the most common cause of non-syndromic hearing loss (HL) in many populations. In the East Asian population, two variants, p.V27I (c.79G>A) and p.E114G (c.341G>A), are considered benign polymorphisms since these variants have been identified in both HL patients and normal hearing controls. However, some stu...

Vitellogenin (Vg) is a well-known nutritious protein involved in reproduction nearly all oviparous animals, including insects. Recently, Vg has been detected saliva proteomes of several piercing–sucking herbivorous arthropods, the small brown planthopper (Laodelphax striatellus, SBPH). Its function, however, remains unexplored. We investigated molecular mechanism underlying SBPH orally secreted...

Synchronized brain rhythms, associated with diverse cognitive functions, have been observed in electrical recordings of brain activity. Neural synchronization may be well described by using the population-averaged global potential VG in computational neuroscience. The time-averaged fluctuation of VG plays the role of a "thermodynamic" order parameter O used for describing the synchrony-asynchro...

OBJECTIVE To compare the efficacy and safety of luteal phase support in IVF with a progesterone (P) vaginal ring or gel (VR or VG). DESIGN Prospective, randomized, single-blind, multicenter, phase III clinical trial (ClinicalTrials.gov identifier: NCT00615251). SETTING Nineteen private and three academic high-volume U.S. IVF centers. PATIENT(S) One thousand two hundred ninety-seven infert...

This case presentation explores how two key Drosophila morphogens, Decapentaplegic (Dpp) and Wingless (Wg), control the expression of two wing disc transcription factors, Vestigial (Vg) and Distalless (Dll). Two simple models for the potential control of Vg and Dll expression by Dpp and Wg in the mature steady state Drosophila wing pouch are explored. Firstly, a model based on the activation me...

BACKGROUND Prolonged mechanical ventilation, longer hospital stay, and a lower rate of home discharge have been reported with patient-ventilator asynchrony in medical patients. Though commonly encountered, asynchrony is poorly defined within the traumatically injured population. METHODS Mechanically ventilated trauma patients at an urban, level-1 center were enrolled. Breath waveforms were re...

The field-effect enzymatic detection (FEED) technique was used to control the kinetics of the enzymatic conversion of glucose to gluconolactone. The glucose-gluconolactone conversion occurring at an enzyme-immobilized electrode, a well-studied process, was confirmed using mass spectrometry. Electrochemical studies showed that the glucose oxidation current depends on the gating voltage VG and th...

The presence of a "status quo" hormone like JH has not been found in ticks. The most advanced understanding of tick endocrinology is associated with female reproduction, where the sequence of the first messages for storage proteins (vitellogenin (Vg) and carrier protein), the Vg receptor, and male peptidic pheromones were recently reported. The current consensus model suggests that ecdysteroids...

In the last decade there has been a drastic increase in the penetration of variable generation (VG) such as wind and solar. VG increases the MW variability that must be met in the regulation and reserve markets. If VG penetration levels are allowed to increase without providing additional flexibility in the form of fast response regulation, reserves, and capacity, then the required capabilities...