Background: This study was targeted toward comparing volume-guaranteed (VG) ventilation with conventional pressure-controlled (PC) ventilation in preterm infants with respiratory distress syndrome (RDS) in terms of the facilitation of weaning and extubation and occurrence of complications, such as pneumothorax, intraventricular hemorrhage (IVH), retinopathy of prematur...

INTRODUCTION The effects of different mechanical ventilation (MV) modes on mortality outcome in infants with respiratory distress syndrome (RDS) are not well known. METHODS We searched the Cochrane Central Register of Controlled Trials (CENTRAL) in the Cochrane Library, EMBASE, MEDLINE, CINAHL, and Web of Science for studies published through April 2014 that assessed mortality in infants with...

Lung-sparing medical ventilation –CPAP + PSV Mode – The FABIAN HFO is a new medical ventilator that was developed mainly for use with newborns and can accommodate children weighing up to 30 kg. It is equipped for ventilation modes CMV, SIMV, AC, PSV, and HFO and has VG, volume limit, and leak correction functions. A key feature is separate pressure setup for backup ventilation during apnoea in ...

Platelet preparations promote bone regeneration by inducing cell migration, proliferation and differentiation in the area of the injury, which are essential processes for regeneration. In addition, several studies have indicated that simvastatin (SIMV), widely used for the treatment of hypercholesterolemia, stimulates osteogenesis. The objective of this study was to evaluate the effects of trea...

OBJECTIVE Widespread death of implanted cells hampers stem cell therapy for acute myocardial infarction (AMI). Based on the pleiotropic beneficial effects of statins, we examined whether simvastatin (SIMV) increased the efficacy of mesenchymal stem cell (MSC) transplantation after AMI. METHODS AND RESULTS Chinese miniswine (n=28) were randomized to 1 of 4 groups (n=7 per group): control, SIMV...

After its development as a weaning modality in the early 1970s,1 intermittent mandatory ventilation (IMV) quickly became a very popular mode of ventilation. Continuous mandatory ventilation, the prevailing mode in use prior to the introduction of IMV, permitted the patient to determine the number of ventilator breaths by sensing patient inspiratory effort. In contrast, IMV mode delivered a set ...

OBJECTIVE Physiologic and pathologic comparison of two modes of assisted ventilation, nasal intermittent positive-pressure ventilation (NIPPV) and synchronized intermittent mandatory ventilation (SIMV), in spontaneously breathing term newborn piglets with saline lavage-induced lung injury. DESIGN After inducing acute lung injury via repetitive saline lavage, piglets were randomized to NIPPV (...

Statins exhibit neuroprotective effects after spinal cord injury (SCI). However, the molecular mechanism underlying these effects remains unknown. This study demonstrates that the hydroxymethylglutaryl coenzyme A reductase inhibitor simvastatin (Simv) exhibits neuroprotective effects on neuronal apoptosis and supports functional recovery in a rat SCI model by activating the Wnt/β-catenin signal...

This prospective study compared two weaning modalities in COPD patients requiring mechanical ventilation (MV) for acute respiratory failure. Nineteen patients with COPD were studied when their precipitating illness was controlled. Although they satisfied the conventional bedside weaning criteria, they could not tolerate any reduction in the respirator rate below 10 cycles/min. At this time, pat...