mammalian expression systems, due to their capacity in post-translational modification, are preferred systems for biopharmaceutical protein production. several recombinant protein systems have been introduced to the market, most of which are under clinical development. in spite of significant improvements such as cell line engineering, introducing novel expression methods, gene silencing and pr...

This study is based on the concept of converting agricultural waste into green new energy, we combine cycle development and relevant theories in modern system engineering to optimize production recycling network. In this paper, optimization network divided two aspects—facility site selection vehicle path planning—with objectives minimization construction operational costs. study, planning probl...

Manufacturers need to satisfy consumer demands in order to compete in the real world. This requires the efficient operation of a supply chain planning. In this research we consider a supply chain including multiple suppliers, multiple manufacturers and multiple customers, addressing a multi-site, multiperiod, multi-product aggregate production planning (APP) problem under uncertainty. First a n...

This paper addresses the Generic Materials and Operations Planning (GMOP) problem, a multi-site operations planning problem based on the “stroke” concept. The problem considers a multinational company subject to positive and negative backlogs imposed by using returnable racks that have to be filled by end products and transported to customers, alternative operations (purchase, transformation an...

New practical applications of the Line of Balance technique are presented, introducing simple and transparent tools for initial planning, short term scheduling and production control on multi-storey building construction sites. These developments were being conducted along an investigation on some construction sites on Brazil. The planning methodology is discussed including preplanning details ...

In this paper, a general multi-level decomposition based framework has been proposed for integration of planning and scheduling in a multi-site, multi-product plant, with applications to paper manufacturing. The problem involves complex issues relating to large-scale production in a hybrid flowshop configuration, decisions relating to minimizing trim losses, while maintaining on-time delivery o...

Anaerobic decomposition of organic compounds in landfills is responsible for generation of greenhouse gases. The present study aimed to determine the total gas and methane emission from a landfill located in Hamedan (west of Iran) from 2011 to 2030. LandGEM 3.02 model was used to estimate the gas emission with the volumetric methane percent of 60%, production potential of 107, and methane gener...

Batch sizing in different planning period is categorized as a classical problem in production planning, that so many exact & heuristic methods have been proposed to solve this problem, each of which considering various aspects of the original problem. The solution obtained from majority – e.g. MRP – is in this format that there may be some periods of idleness or each period should produce a...

The process of production planning and control contributes significantly to the efficiency of modern production systems. However, common central planning methods in industrial application show deficits in complex and dynamic production environments. In contrast to prevailing central control methods, approaches of autonomous control offer the chance to cope with these dynamic conditions more eff...

Automation of the re-planning process is an activity of immense importance in production planning systems. We introduce a novel perspective on production planning through substituting classical scheduling and planning mechanism with the process of job delegation and responsibility negotiation among information units – agents of a multi-agent systems. The article comments on various causes and m...