Members of the Sox (Sry-related high mobility group box) family of transcription factors play a variety of roles during development of both vertebrates and invertebrates. A marked expansion in gene number occurred during the emergence of vertebrates, apparently via gene duplication events that are thought to have facilitated new functions. By screening a macroarrayed library as well as the lamp...

Oct4 and Sox2 regulate the expression of target genes such as Nanog, Fgf4, and Utf1, by binding to their respective regulatory motifs. Their functional cooperation is reflected in their ability to heterodimerize on adjacent cis regulatory motifs, the composite Sox/Oct motif. Given that Oct4 and Sox2 regulate many developmental genes, a quantitative analysis of their synergistic action on differ...

Prior research has paid very little attention, if at all, to the risks and costs entailed in IT disintegration processes. In this study, we begin addressing this gap by studying how IT disintegration challenges posed by corporate divestitures affect the regulatory compliance risks and costs of divesting firms in the context of the Sarbanes-Oxley Act of 2002 (SOX). We hypothesize that firms with...

Three chicken Sox (SRY-like box) genes have been identified that show an interactive pattern of expression in the developing embryonic nervous system. cSox2 and cSox3 code for related proteins and both are predominantly expressed in the immature neural epithelium of the entire CNS of HH stage 10 to 34 embryos. cSox11 is related to cSox2 and cSox3 only by virtue of containing an SRY-like HMG-box...

ABC Fax + 41 61 306 12 34 E-mail [email protected] www.karger.com © 2002 S. Karger AG, Basel 0301–0171/02/0981–0096$18.50/0 Accessible online at: www.karger.com/cgr Abstract. Group B SOX genes, the closest relatives to the sex-determining gene SRY, are thought to have evolved from a single ancestral SOX B by a series of duplications and translocations. The two SOX B genes SOX2 and SOX14 co-local...

The Sarbanes-Oxley Act (SOX) of 2002 places significant and costly new burdens on public companies. Meeting the recurring requirements for financial reporting under SOX effectively will demand innovative application of information technology. The Continuous Auditing Web Services model (CAWS) provides a framework for considering how to efficiently manage and automate financial reporting. We prop...

in of e n factor containing a 79-amino-acid DNA-binding domain known as the HMG box (Capel and Lovell-Badge, 1993). Many genes have now been cloned on the basis of their homology to the HMG box of Sry and comprise the Sox gene family, for Sry-related HMG box-containing genes. Approximately 20 Sox genes have been found in mammals, with more being identified in other vertebrates and invertebrates...

The early lytic phase of Kaposi's sarcoma herpesvirus infection is characterized by viral replication and the global degradation (shutoff) of host mRNA. Key to both activities is the virally encoded alkaline exonuclease KSHV SOX. While the DNase activity of KSHV SOX is required for the resolution of viral genomic DNA as a precursor to encapsidation, its exact involvement in host shutoff remains...

SOX-domain proteins are a class of developmentally important transcriptional regulators related to the mammalian testis determining factor SRY. In common with other SOX-domain genes, the Drosophila Dichaete gene has a dynamic expression profile in the developing central nervous system, including cells of the ventral midline. We find defects in the differentiation of midline glia and concomitant...