Timolol is a non-selective beta-adrenergic receptor antagonist administered for treating glaucoma, heart attacks and hypertension. In the present study, we set out to determine whether or not timolol can provoke cataract formation, thus the influence of timolol on the amyloid-type aggregation of crystallin was investigated. We then provided experimental evidence of crystallin aggregation and it...

Introduction: Effects of melatonin (MT) were comparatively examined on melanophores of isolated skin in adults and tadpole’s tailfin of a frog Rana cyanophlyctis. MT is generally considered as a potent melanophores aggregating hormone besides regulating the sleep wake cycle in vertebrates. Methods: Melanophore size index (MSI) was chosen as a recording parameter of the responses. Concentr...

Multiple lines of evidence substantiate the existence a very large aggregation basketwork eel, Diastobranchus capensis, on small (3 km2) Patience Seamount off southeast Australia. The appears to be present year-round, but largest in austral autumn when composed spawning eels. Twenty eels caught April 2015 (14 female, 6 male) were all advanced stages condition. eel’s abundance was high as measur...

Interactions of 3,3',4,4'-tetrahydroxybiphenyl (BPT) and three isomeric 3,3",4,4"-tetrahydroxyterphenyls (OTT, MTT, PTT) with Alzheimer’s amyloid-β peptide (Aβ) were studied by molecular dynamics simulation and molecular docking. Structural parameters such as Root-mean-square derivations (RMSD), radial distribution function (RDF), helix percentage and other physical parameters were obtained. Th...

Several fuzzy connectives, including those proposed by Lotfi Zadeh, can be seen as linear extensions of the Boolean connectives from the scale ${0,1}$ into the scale $[0,1]$. We discuss these extensions, in particular, we focus on the dualities arising from the Boolean dualities. These dualities allow to transfer the results from some particular class of extended Boolean functions, e.g., from c...

Aloe vera plant (A. vulgari and A. barbadensis) has being used traditionally as a medicinal plant for centuries. Gel from the inner central zone of the leaves and latex from pericyclic cells are used for medicinal purposes. The present study was conducted to elucidate the beneficial effects of Aloe vera juice on the platelet aggregation in cerebral microvessels of mice. Male mice were injected ...

The ingested nitrates sourced from tap water, food, chemicals and pharmaceuticals areconverted to nitrites in the body surfaces by bacteria and then, the nitrite ions can lead thestructural changing in hemoglobin. In the present work, aggregation of the purified hemoglobinin adult (HbA) and in fetus or newborn (HbF) in the presence of nitrite ions were studied.Hemoglobin aggregation was perform...

Timolol is a non-selective beta-adrenergic receptor antagonist administered for treating glaucoma, heart attacks and hypertension. In the present study, we set out to determine whether or not timolol can provoke cataract formation, thus the influence of timolol on the amyloid-type aggregation of crystallin was investigated. We then provided experimental evidence of crystallin aggregation and it...

objective(s): this paper describes a selective and sensitive biosensor based on the dissolution and aggregation of aptamer wrapped single-walled carbon nanotubes. we report on the direct detection of aptamer–cocaine interactions, namely between a dna aptamer and cocaine molecules based on near-infrared absorption at λ807. materials and methods: first a dna aptamer recognizing cocaine was non-co...