A new study by Ito and colleagues on page 7 may help explain why patients with a severe lung disease called chronic obstructive pulmonary disease (COPD) fail to respond to steroid treatment. Ito and colleagues show that steroids require the enzyme HDAC2 (histone deacetylase 2) to block the inflammatory transcription factor NF-κB. In patients with COPD, HDAC2 activity is reduced, rendering cells...

Background: Anabolic-androgenic steroids are used at high doses by athletes for improving athletic ability, physical appearance and muscle mass. Therefore, the abuse of these steroids has been significantly increased. Many undesirable side effects of these steroids on the male reproductive function have been reported, however, little is known about their effects on sexual behavior and tissues o...

conclusions the identification of the beneficial cardiovascular effects of dhea (s) and a better understanding of the involved mechanisms should be helpful to develop new strategies or pharmacologic approaches for many lethal diseases in western countries. context dehydroepiandrosterone (dhea) and its sulfate ester, dehydroepiandrosterone sulfate (dhea-s) have been considered as putative anti-a...

this study aimed to assess the prevalence of anabolic steroid usage among high school students in kurdistan state, that cross-sectional design was performed on a sample of 1,006 individuals, who were selected by cluster sampling method. in order to collect data, questionnaire was prepared by researcher and the verified its validity and reliability. the results showed that 79 participates (8%) o...