Mice lacking both the gene encoding the shared receptor for granulocyte macrophage–colony-stimulating factor (GMCSF), interleukin-3 (IL-3), and IL-5 common b-chain (Bc) and the gene for the IL-3 specific receptor (BIL3) were generated. This was achieved by targeting the Bc locus in embryonic stem cells that were heterozygous for a null mutation of BIL3. Cells from mice generated with the doubly...

The present study aimed at investigating the beneficial effects of co-administering granulocyte colony–stimulating factor (G-CSF) and stem cell factor (SCF) in a model of chronic liver injury induced by thioacetamide (TAA). Biochemical and histopathologycal examinations were performed on serum and liver specimens. At the end of the treatment period, the rats were anesthetized with ether, serum ...

A central problem of the current studies on protooncogenes (cellular oncogenes, c-onc) is their role in the control of growth and differentiation of normal cells. The cfos protooncogene has been widely investigated and it has been demonstrated that cfos specific transcripts are induced in proliferating cells (1, 2) and during differentiation (3-6) . In particular, when HL60 (promyelocytic) and ...

The present study was aimed to evaluate the incidences of chemotherapy-induced neutropenia in patients with solid tumors in India. The patients with carcinomas of breast, lung, ovary, colon, head and neck, and liver were divided in two groups. Group 1 was for the patients who experienced grade 0-2 neutropenia and Group 2 was for patients with grade 3-4 neutropenia. Different types of chemothera...

introduction genetic background has known to be associated with the outcome of human t cell lymphotropic virus (htlv) type i infection. in the present study we investigate the association between gm-csf gene polymorphisms with the outcome of htlv-i infection. materials and methods we analyzed 3 single-nucleotide polymorphisms in the promter region of granulocyte macrophage colony stimulating fa...

objective(s): granulocyte-colony stimulating factor (g-csf) is used in clinical practice for the treatment of neutropenia and to stimulate generation of hematopoietic stem cells in bone marrow donors. in the present study, the ability of g-csf in mobilizing exogenous bone marrow stem cells (bmscs) from peripheral blood into the brain was tested. we for the first time injected a small amount of ...

In this study granulocyte-macrophage colony stimulating factor (CSF) was prepared from rabbit and guinea pig lung tissues. The biological activity of these CSFs was measured on semisolid agar culture and compared with those of mouse and rat. Weight of animals, incubation time and cross-reactivity of CSFs with different bone marrow sources were also investigated. The results showed that both...