insulin-like growth factor (igf-1) is an anti-apoptosis factor in multiple cell types associated with various cancers. computational methods allow investigating the systems between 50–100 atoms in the frame of quantum mechanics and up to 50,000 atoms with molecular dynamics. since there are specific interactions between the residues, the solvent could play an important role in the stability of ...

The Harary index H can be viewed as a molecular structure descriptor composed of increments representing interactions between pairs of atoms, such that their magnitude decreases with the increasing distance between the respective two atoms. A generalization of the Harary index, denoted by Hk, is achieved by employing the Steiner-type distance between k-tuples of atoms. We show that the linear c...

By increasing house demand for living, the urban development planning has turned to towers, which provides a platform for the growth of the city, regardless of the traditional Iranian's architecture. Among the vital elements in traditional architecture, there are a variety of open and semi-open spaces such as the central courtyard, pool, veranda, balcony, etc that have been provided the needs f...

Single crystals of Schiff base compound 2-[(2-chloro-4-nitrophenyl) iminomethyl] phenol (1) were grown by the slow evaporation technique at room temperature. The crystal structure of the title compound was determined by single crystal X-ray diffraction. The title compound crystallizes in the monoclinic system, space group P21, with two symmetry independent molecules. Intramolecular O-H···N hydr...

with advances in genetic science, the dynamic structure of eukaryotic genome is considered as basis of gene expression regulation. long-distance communication between regulatory elements and target promoters is critical and the mechanisms responsible for this connection are just starting to emerge. chromatin insulators are key determinants of proper gene regulation and precise organization of c...

The success of urban spaces is proportional to the extent in which that space is being used and to human presence. In fact, architecture and urban planning should attempt to enhance social interactions and human solidarity rather than differentiation and separation. However, today what is witnessed in most of urban spaces is reduction of relationships and social participation of those residing ...