The organic deposition particularly asphaltenes has many detrimental effects on the oil industries, such as plugging in pipelines, wellbore and facilities and subsequently, considerable reduction in well productivity.Asphaltenes are the most polar fractions, which they have been dispersed as colloidal clusters in crude oil. The accumulation of these clusters lead to the flocculation of colloids...

furin is a ca 2+ -dependent serine protease which cleaves proprotein substrates at the arg-xaa-(lys/arg)-arg    site to generate biologically active proteins. furin’s critical role in many cellular events associated with health disorders such as hiv, sars, anthrax, and influenza as well as cancer has made inhibitors of this enzyme as therapeutic targets. to this date, the most potent inhibitor ...

Cancer immunotherapy has gained a lot of interest over the past few years due to the success of immune checkpoint inhibitors in treating cancer (1, 2). Immune checkpoint inhibitors, such as monoclonal antibodies against cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4) and programmed death 1 (PD-1), have been shown to increase survival of patients with advanced cancers (1, 2). These in...

The antitumor properties of (E)-2-(fluoromethyl)dehydroornithine methyl ester (A-MFMO-ME) and of (E)-2-(fluoromethyl)dehydroornithine ethyl ester (A-MFMO-EE), the prodrugs of A-MFMO, an irreversible inhibitor of mammalian L-ornithine decarboxylase (ODC) 14 times more potent than a-difluoromethylornithine (DFMO) and equipotent to (2R,5R)-6-heptyne-2,5-diamine (MAP) in vitro, have been inves tiga...

background & aim: recent researches have been done on effects of plant growth regulators (pgr) on growth and production of different crops whose results indicate the effectiveness of most of these hormones on qualitative and quantitative growth of herbs. the application of regulators and inhibitors of growth on herbs may, in addition to growth, also lead to secondary metabolites stimulation...