Colebrook & Kenny (1936), Colebrook, Buttle & O'Meara (1936) and, later, others showed that some time must elapse after bacteria are inoculated into media containing sulphonamide before an inhibitory effect is produced. Multiplication of the organism occurs in the interval. Subsequently, Wolff& Julius (1939) concluded that sulphonamides act on bacteria only when they are multiplying, and O'Mear...

A Novel compound namely N-(Nicotinoyl) 3,5 dimethyl-4-(N-4-sulfamoylazo)-1,2-diazole has been synthesised by two step processes. Synthesis of N-4-sulphamoylphenylhydrazono-3,5-dimethyl propane1,3-dione and sulphonamide, which interacting with Nicotinic acid hydrazide to form final compound. The newely synthesised compound N-(nicotinoyl)-3,5-dimethyl 4-(N-4-sulfamoyl phenyl azo) 1,2-diazoles was...

The aim of this study was to screen for the presence of antimicrobial resistance genes within the saliva and faecal microbiomes of healthy adult human volunteers from five European countries. Two non-culture based approaches were employed to obviate potential bias associated with difficult to culture members of the microbiota. In a gene target-based approach, a microarray was employed to screen...

(a) Severe prostration occurs with a high fever, and symptoms of widespread disease. The heart, meninges, kidneys, pleurae, liver, and skin may be involved. This type of sepsis has a grave prognosis and before the sulphonamide-antibiotic era 80 to 90 per cent. of patients with endocarditis died (Burckhardt, 1964). (b) The patients are febrile but not severely ill, joint and skin symptoms domina...

While discussing with the writers the problem of treatment of leptospiral infection by synthetic drugs, Mr. Harold Walker, representative of Messrs. May and Baker, Ltd., suggested that the effectiveness of soluseptasine, which like other compounds of the sulphonamide group has earned a great reputation for its bactericidal properties, particularly in streptococcal infections, might be tested on...

It has generally been considered unsafe to give onions, eggs and other sulphur-containing foodstuffs, as well as medicines containing sulphur, to a patient who is receiving the sulphonamide group of drugs. It has been said that the sulphur moiety may lead to sulphsemoglobinsemia which causes cyanosis; the sulphsemoglobin, not being reconvertible into haemoglobin, reduces the oxygen-carrying cap...

Mercury resistance is found in many genera of bacteria. Common amongst enterobacteria are transposons related to Tn21, which is both mercuric ion- and streptomycin-/spectinomycin- and sulphonamide-resistant. Other Tn21-related transposons often have different antibiotic resistances compared with Tn21, but share many non-antibiotic-resistance genes with it. In this article we discuss possible me...