The antibiotic resistance of Staphylococcus aureus isolated in Bristol from primary skin sepsis and nasal carriers outside hospital was recorded between 1949 and 1969. The proportion of penicillinase-forming strains rose to about 60% but resistance to other antibiotics remained un-common except for a peak about 1957, due to the spread of multiresistant phage-type 80 staphylococci. Reasons are d...

A series of tertiary sulphonamide derivatives were synthesised and evaluated for their antiproliferative activity against liver cancer cell lines (SNU-475, HepG-2, Bel-7402). Among these sulphonamides, compound 17a displayed the best anti-liver Bel-7402 cells with an IC50 value 0.32 μM. Compound could effectively inhibit tubulin polymerisation 1.27 Meanwhile, it selectively suppressed LSD1 63 n...

Veterinary and human medicines containing a sulphonamide are used to prevent infections in a variety of situations. For sulphonamide products that contain many components (e.g. four or more sulphonamides) chromatographic techniques are recommended [l-5]. However, for products formulated to contain a sulphonamide and another drug which increases the activity of the sulphonamide, simple, rapid an...

OBJECTIVES We investigated whether sulphonamide resistance in Escherichia coli remained prevalent in 2004, 9 years since the formal introduction of a UK prescribing restriction on co-trimoxazole. Resistance to other agents no longer in common use was also examined. METHODS Consecutive urinary E. coli isolates were obtained at the diagnostic microbiology laboratory of the Royal London Hospital...

BACKGROUND The Cinnoline moiety and Sulphonamide moiety both have good antimicrobial properties. METHODS In the present study both the moieties were condensed to synthesize substituted cinnoline sulphonamide derivatives using intramolecular cyclization followed by diazotization in order to get synergistic activity. RESULTS These derivatives particularly halogen substituted cinnoline derivat...

A Mohammedan male, aged 15 years, was admitted to the surgical ward of this hospital on 29th December, 1945, for osteomyelitis of the right leg. A course of sulphonamide two tablets thrice daily was prescribed and the leg was operated on. Ten days later he showed signs of pain and fullness over the back and loin, and there was complete anuria. Sulphonamide was at once stopped, and alkaline mixt...