ЖУРНАЛ НЕВРОЛОГИИ И ПСИХИАТРИИ, 6, 2012 Бурное развитие психофармакологии, произошедшее в последние десятилетия, привело к введению в практику большого количества новых антипсихотических средств. Рисперидон, палиперидон, оланзапин, кветиапин, сертиндол, зипрасидон, арипипразол и другие атипичные нейролептики прочно заняли свои позиции в арсенале психиатров, значительно потеснив «старые», традиц...

Weight gain, obesity and hyperprolactinemia are important complications of long-term administration of neuroleptic drugs, which may affect the patient's general health and well- being that itself interferes with treatment compliance. The purpose of this study was to identify the mechanism of occurrence of these side-effects. Because of the important role of ventromedial nucleus of hypothalamus ...

Background: Male infertility is a widespread problem and increased number of mast cells-induced by some drugs like sulpiride atipycal antipsychotic drug, ara described in the testis of males, exhibiting impaired sper-matogenesis and fertility disorders. In this study number of mast cells and sertoli cells, thickness of seminiferous tubule’s lamina propria and sperm concentration and viability i...

Anxiety-related behaviors increase histamine and dopamine release in the brain. On the other hand, central histamine counteracts reward and reinforcement processes mediated by the mesolimbic dopamine system. We investigated the effects of the histaminergic system and dopamine D2 receptors agents and their interactions on anxiety-related behaviors using the elevated plus-maze (EPM). The intra-hi...

The aim of the present study was to evaluate the effect of antidopaminergic agents on the somatotrophs in the presence of hyperprolactinemia. Adult male Wistar rats were divided into 6 groups: a control group and five groups chronically treated (60 days) with haloperidol, fluphenazine, sulpiride, metoclopramide or estrogen. Somatotrophs and lactotrophs were identified by immunohistochemistry an...

The role of dopamine receptors in the modulation of nucleus accumbens noradrenaline release was investigated in superfused rat brain slices. At concentrations of </=1 microM, dopamine enhanced, whereas at higher concentrations dopamine inhibited electrically evoked [3H]noradrenaline release. The D1 receptor agonist SKF-38393 increased, whereas the D2 agonist quinpirole inhibited evoked [3H]nora...

In animal models of retinitis pigmentosa the dopaminergic system in the retina appears to be dysfunctional, which may contribute to the debilitated sight experienced by retinitis pigmentosa patients. Since dopamine D2-like receptors are known to modulate the activity of dopaminergic neurons, I examined the effects of dopamine D2-like receptor antagonists on the light responses of retinal gangli...

TRH, arginine, L-dopa, and sulpiride tests for PRL secretion were carried out in 18 control subjects and 20 patients with pituitary PRL-secreting adenomas before and after hypophysectomy. After the hypophysectomy PRL levels fell to normal ranges in 9 cases (categorized as Group I), and remained high in 11 other cases (categorized as Group II). After the operation, there were no alterations of P...

Regulation of dopamine receptor subtypes was determined after long-term (8 mo) administration of typical and atypical antipsychotic drugs using 3H-nemonapride, 3H-raclopride, 3H-spiperone, 3H-7-hydroxy-N,N-di-n-propyl-2-aminotetralin, 3H-SCH23390 and 125I-sulpiride in vitro receptor autoradiography. Drug-induced receptor upregulation was remarkably different across the various D2-like receptor ...