Ahmadi A
[ 2 ] - P-140: Protective Effects of Imedeen on Oxidative Stress Induction Spermatogenic Disorders and Fertility Potential of Cyclophosphamide-Treated Male NMRI Mice
Background: Imedeen tablets are revolution in anti-aging skincare. This tablets contains Biomarin complex (rich in natural proteins and Marin polysaccharides) and Lycophence GS complex rich in grape seeds extract and lycophence antioxidant,helps to give the skin protection against both direct and indirect damage that caused by free radicals.Cyclophosphamide as an anticancer agent has been known...
[ 3 ] - P-161: Deleterious Side Effects of Methotrexate on In Vitro Fertilization and Protective Role of Cornus Mas Extract in Adult Mice
Background: Because of stress oxidative side effect of MTX on reproductive system, current study was aimed to evaluate protective effects of cornus mas fruit extract (CMFE) in mice treated with methotrexate (MTX). Materials and Methods: 48 young mature male mice were classified in 4 groups. Control group received only normal saline orally (0.2 ml/day), and the second group was administered MTX ...
[ 5 ] - P-241: Association of ITPA Polymorphisms rs1127354 with Infertility
Background: Infertility is a relatively common problem that affects couples worldwide. It is estimated that approximately 1 in 6 couples will experience difficulties in reproducing, defined as a failure to conceive after two years of unprotected sexual intercourse. The molecular and genetic factors underlying the cause of infertility remain largely undiscovered. ITPA is an inosine triphosphatas...
[ 6 ] - P-252: Protective Effects of Imedeen on Oxidative Stress Induction Spermatogenic Disorders and Fertility Potential of Cyclophosphamide-Treated Male NMRI Mice.
Background: cyclophosphamide is anticancer agent that has been toxic effects on male reproductive system.The antioxidant agents in imedeen such as lycophence GS and Biomarine complex play important role in preventing the direct and indirect effects of free radicals caused by CP; therefore, the purpose of this study was to evaluate the effects of Imedeen on sperm characteristics of mature male m...
[ 7 ] - P-10: Ethyl Pyrovate Repopulate The Leydig and Sertoli Cells in Testis of Cyclophosphamide Treated Adult Mice
Background: Increases in the survival rate of men treated with chemotherapeutic drugs and their desire to have children precipitate concerns about the effects of these drugs on germ cells. This study performed to evaluation of protective effects of ethyl pyrovate in oxidative stress induced by cyclophosphamide (CP) on testis. Materials and Methods: Three groups (6 mice in each) of adult mice we...
[ 8 ] - P-29: Crocin Down-Regulated The Cyclophosphamid-Increased Follicular Atresia in Mice
Background: Although the chemotherapeutic agents have been known for their cytotoxic effects on normal mammalian cells, these compounds are used widely for controlling the carcinogenic cells proliferation. Cyclophosphamide (CP), a well-known nitrogen mustard alkylating agent is used for autoimmune disorders and tumors treatment. Considering the inhibitory effect of CP on cell division, the ovar...
[ 9 ] - P-61: Comparing The Protective Effects of Hydro-Alcoholic Extract of Cornus Mas Versus Vitamin E on Methotrexate-Induced Damages on Sperm Parameters
Background: Methotrexate (MTX), as antimetabolite and antifolate compound, is used to treat the certain types of tissue over activity and cancers. The MTX interferes with cell division through inhibiting the purine and pyrimidine synthesis. Moreover, the toxic impact of the MTX on gonadal tissues has been reported. Therefore, current study was designed to evaluate the protective effects of corn...
[ 10 ] - P-67: Reactive Oxygen Species, MDA and NO Concentration of Testicular Extract and Their Effect on Sperm Parameters and IVF Outcome in Hyperprolactinemic Adult Male Mice
Background: ROS are free radicals that have a significant role in many of the sperm physiological processes. In the presence of polyunsaturated fatty acids such as sperm plasma membrane,ROS triggers a chain of chemical reactions called lipid peroxidation.The aim of this study was to determine and compare the concentration of MDA and NO in testicular extract of hyperprolactinemic adult male mice...
[ 11 ] - P-74: Crocin Repopulate The Leydig and Sertoli Cells in Testis of Cyclophosphamide Treated Adult Mice
Background: Increases in the survival rate of men treated with chemotherapeutic drugs and their desire to have children precipitate concerns about the effects of these drugs on germ cells. This study performed to evaluation of protective effects of crocin in oxidative stress induced by cyclophosphamide (CP) on testis. Materials and Methods: Three groups (6 mice in each) of adult mice were used....
[ 12 ] - P-3: Effects of Increased Mast Cells Number-Induced by Sulpiride Atipycal Antipsychotic Drug on Sertoli Cells and Sperm Production in Adult Male Mice
Background: Male infertility is a widespread problem and increased number of mast cells-induced by some drugs like sulpiride atipycal antipsychotic drug, ara described in the testis of males, exhibiting impaired sper-matogenesis and fertility disorders. In this study number of mast cells and sertoli cells, thickness of seminiferous tubule’s lamina propria and sperm concentration and viability i...
[ 13 ] - P-4: Effect of Reduced FSH Serum Concentration Induced by Sulpiride Atypical Antipsychotic Drug on Repopulation Index and Number of Primery Spermatocyte Cells in Adult Male Mice
Background: Usage of some atipycal antipsychotic drugs like sulpiride has severed effects on male fertility by impressions on sexual hormones secretion. These hormones regulate male germ cells proliferation and differentiation. In the present study we sought to elucidate the impact of sulpiride on serum prolactin and FSH concentration. Also effect of FSH on spermatogonium A/B (repopulation inde...
[ 14 ] - P-5: Evaluation of The Effect of Sulpiride As An Atypical Antipsychotic Drug, on The Serum Levels of Prolactin, LH, FSH and Testosterone in Adult Male Mice
Background: Prescription of the atypical antipsychotic drugs like as Sulpiride for the treatment of schizophrenic patients was increased because of their less side effects. This study was aimed to evaluate the effect of sulpiride on hormonal milieu of adult male mice namely their serum level of prolactin and sexual hormones. Materials and Methods: 24 adult male mice were divided in three groups...
[ 15 ] - P-7: Testosterone and Gonadotrophin Hormones Plasma Concentration-Induced Changes in Sertoli and Leydig Cells Number in Hyperprolactinemic Mature Male Mice
Background: Hyperprolactinemia is a particular concern in the treatment of schizophrenic patients. The side effects associated with high prolactin levels can have a negative impact on GnRH pulsatile secretion and, consequently LH, FSH and testosterone pulsatility and follows by, on special testicular cells that have these hormon’s receptors such as sertoli and leydig cells. Quantification the d...
[ 16 ] - P-28: The Protective Effect of Equisetum Arvense Alcoholic Extract on Sperm Quality, DNA Damage and Sperm Abnormalities in Streptozotocin Induced Diabetic Male Mice
Background: Diabetes mellitus as a chronic disease can cause fertility problems in male human population. In fact, it exerts sever damages in testicular tissue and subsequently reduces total number of normal sperms and semen volume. Therefore, this study is designed to evaluate the protective effect of Equisetum arvense extract on sperm quality, DNA damage and maturation in diabetic male mice. ...
[ 17 ] - P-58: Mast Cells in Interstitial Tissue in The Testis of Male Rats Treated with Acyclovir
Background: Acyclovir (9-(2-hydroxyethoxymethyl) guanine) (ACV) is an acyclic nucleoside analogue that has shown a potent antiviral activity, and it is known to inhibit the replication of herpesviruses including herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), varicella- zoster virus (VZV), and Epstein-Barr virus (EBV) in cell cultures and in animals. ACV is khown to be toxic to gonads,t...
[ 18 ] - P-67: Nano-Selenium Protects Cisplatin-Induced Spermatotoxicty and Chromatin Abnormality Associated with Free Radicals Toxic Stress
Background: Cisplatin (CIS), an anticancer alkylating agent, induces DNA adducts and effectively cross links the DNA strands and so affects spermatozoa as a male reproductive tract toxicant. Materials and Methods: The present study investigated the cellular/biochemical mechanisms underlying possible protective effect of selenium nano-particles (Nano-Se) as an established strong antioxidant with...
[ 19 ] - P-88: Mast Cells Number and Distribution and Myoid Cells Population Are Impressed by Sulpiride Antipsychotic Drug
Background: Spermatogenesis is under the control of variety of factors, which include mast cells. Any changes in testicular mast cells’ number and distribution resulting in deterioration of comlex regulation and fine-turning of spermatogenesis. Increased number of mast cells and their abnormal spread pattern have been described in the testis with fertility disturbances. Mast cells’ tryptase enz...
[ 20 ] - P-105: Study of The Protective Effect of Equisetum Arvense Alcoholic Extract on In Vitro Fertilization and Embryo Development in Diabetic Male Mice
Background: Diabetes is a metabolic disorder that in long period can damage the testis and reduce the semen quality. Therefore, it can impair the male fertility potential. Recently, different herbal therapeutic treatment for protection of diabetes and its pathologic effects have been used. The aim of current study is to evaluate the protective effect of Equisetum arvense extract (EE) on in vitr...
[ 21 ] - P-188: Mammary Gland Changes during Chlorpromazine Treatment in Female Rats
Background: Antipsychotic drugs are medications used to treat schizophrenia and other psychotic disorders. Antipsychotic drugs can cause unwanted side effects. Hyperprolactinemia is an important but neglected adverse effect. The aim of the this study was to consider the effects of Chlropromazine -induced hyperprolactinaemia on mammary glands of female rats . Materials and Methods: In this study...
[ 22 ] - P-216: The Protective Effect of Saturejakhuzistanicaagainst Female Mice Follicle Defects Induced by Busulfan
Background: In the past 2 decades, the survival rates for many of the malignancies that affectyoung women have significantly improved. For many of these malignancies, survival rates exceed 80-90%. Therefore, the remote effects of cancer treatment have recently gained worldwide interest, andthe protection against iatrogenic infertility caused by chemotherapy assumes high priority. Busulfan is a ...
[ 23 ] - P-226: American Ginseng Effects on Damage Induced by Cyclophosphamide in The Nuclei of Rat Sperm
Background: Oxidative stress occurs when the oxidative homeostasis is damage. Excessive ROS are generated and this reaction has been proposed to produce marked damage to the structure and function of sperm. Materials and Methods: This study was designed to investigate the protective effects of of American Ginseng against cyclophosphamide - induced damage in the rat sperm. For this experiment, t...
[ 24 ] - P-230: Low Pregnancy Rate in Female Rats Mated by Male Rats Exposed to Acyclovir
Background: Acyclovir [9-(2-hydroxyethoxymethyl)guanine; ACV], an acyclic nucleoside analogue, has shown a potent antiviral activity. It is known to inhibit the replication of herpes viruses including herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), varicellazoster virus, and Epstein-Barr virus in cell cultures and in animals. ACV is khown to be toxic to gonads,then the aim of the presen...
[ 25 ] - P-237: Chronic Alcoholism Induced Male Infertility :Impairment of Sperm Quality
Background: Prolonged alcohol abuse in men can cause testosterone deficiency and shrinkage of the testicles (testicular atrophy). This can lead to impotence, sterility and ‘feminisation’. When alcohol is broken down in the body, it may also interfere with normal sperm structure and movement. This study was designed to determine the effects of administration of alcohol on sperm quality, sperm ma...
[ 26 ] - P-238: Evaluation of The Effect of Ethanol Consumption on Testis Tissue in Mice
Background: Alcohol affects reproduction in both men and women in a number of ways. Chronic exposure to ethanol may results in pathophysiologic changes in cellular function. The present work was designed to investigate the morphology of testis submitted to experimental ethanol ingestion. Materials and Methods: Twenty adult male mice were divided in 2 groups: control sham (salin normal) and test...
[ 27 ] - P-58: Evaluation of Ovarian Toxicity Effects of Chlorpromazine in Female Rats
Background: Elevations in serum prolactin levels (hyperprolactinaemia) are a common side effect of conventional antipsychotic treatments. The main objective of this study was to consider the effects of the antipsychotic drug chlorpromazine (CPZ) in female rats reproductive system and to examine the relationship between the effects on reproductive organs and hormone concentrations. Materials and...
[ 28 ] - P-59: Low IVF Rate and Embryonic Development in Ciprofloxacin-Treated Male Mice
Background: In the last few years, a marked decrease in male fertility has been reported. Environmental factors were recently suspected for this problem. The misuse of medicines especially antibiotics are among environmental factors that can affect reproductive system. Ciprofloxacin is a synthetic antibacterial agent belonging to the family of fluoroquinolones with a very broad spectrum effect ...
[ 29 ] - P-25: Study of the Effect of Experimental Diabetes Induced by STZ on In vitro Fertilization and Preimplantation Embryo Development Rate in Male Mouse Model
Background: Diabetes is a metabolic disease caused by a deficiency in the pancreatic secretion of insulin and/or by the inability of tissues to efficiently respond to insulin, events that cause hyperglycemia and affect all organs.Tissue alterations caused by diabetes affect different organic systems , including the male reproductive system. Reproductive dysfunction is one of the common secondar...
[ 30 ] - P-26: The Effect of Zygote and 2-cell Development Stages on Vitrification Process of Mouse Embryo
Background: While it is possible to routinely cryopreserve embryos from several mammalian species, the cryopreservation of embryos has largely been limited by their high sensitivity to chilling injury. Many factors such as the stage of embryonic development, cryoprotectant toxicity, the composition of the vitrification solution and cooling and warming rates can influence survival of embryos aft...
[ 31 ] - P-31: Evaluation of In vitro Fertilization Rate, Embryo Quality and Development in Experimental Model of Diabetes induced by STZ: in Female Mouse
Background: Diabetes mellitus is a metabolic condition characterized by elevated blood glucose levels secondary to absolute impairment of insulin secretion. Maternal diabetes has been demonstrated to adversely affect pre implantation embryo development and pregnancy outcomes. Emerging evidence has implicated that these effects are associated with compromised oocyte competence. Several developme...
[ 32 ] - P-50: The Effect of Sulpiride on Reproductive System in Female Rats
Background: Sulpiride is a substituted benzamide derivative and a selective dopamine D2 antagonist with antipsychotic and antidepressant activity. Sulpiride is effective in the treatment of acute and chronic schizophrenia.Sexual function is multifaceted and is affected in many ways by schizophrenia and the antipsychotic drugs used in its treatment . Sulpiride are associated with elevation of pr...
[ 33 ] - P-51: A Purine Nucleoside Analogue_Acyclovir Impairs Testicular Functions in Male Rats
Background: Acyclovir (ACV) is a synthetic purine nucleoside analog drived from guanosine. ACV possesses antiviral activity against Herpes Simplex Virus types 1 and 2 (HSV-1 and HSV-2 ), Varicella Zoster virus (VZV) , Epstein Barr virus (EBV) and Cytomegalovirus (CMV). ACV exert its effects by interfering with DNA synthesis,thus inhibiting viral replication. ACV is khown to be toxic to gonads,t...
[ 34 ] - P-52: Acyclovir Induced Sperm and Hormonal Disorders in Male Rats
Background: Acyclovir is asynthetic purin nucleoside analog,which has been reported to be very effective against the treatment of herpes simplex and varicella zoster infections. Acyclovir is known to be toxic to gonads, but available literature fails to provide the indepth analyses of damage.The aim of the present study was to evaluate the effect of Acyclovir on DNA damage and nuclear maturatio...