Background: Systemic candidiasis is a major complication in neutropenic cancer patients undergoing treatment. Most systemic fungal infections emerge from endogenous microflora so the aim of the present study was to identify Candida species isolated from the different regions of body   in neutropenic patients in compare with the control group. Methods: A total of 309 neutropenic can...

Combined hepatocellular cholangiocarcinoma (cHCC-CCA) is a rare subtype of primary liver cancers. Therapeutic strategies for patients with cHCC-CCA are limited, and no standard systemic treatment has been established unresectable cHCC-CCA. Here, we present six cases treated atezolizumab plus bevacizumab. We observed three partial responses one stable disease as the best responses; two these wer...

Abstract Background Skin cancers are among the widely prevalent forms of cancer worldwide. The increasing industrialization and accompanied environmental changes have further worsened skin statistics. stern topical barrier although difficult to breach is a little compromised in pathologies like cancer. therapeutic management has moved beyond chemotherapy surgery. Main body abstract quest for ma...

Over the last 30 years, genetically engineered DNA has been tested as novel vaccination strategy against various diseases, including human immunodeficiency virus (HIV), hepatitis B, several parasites, and cancers. However, clinical breakthrough of technique is confined by low transfection efficacy immunogenicity employed vaccines. Therefore, carrier materials were designed to prevent rapid degr...

BACKGROUND The purpose of this study is to characterize the risk of cancer in a large cohort of patients with primary Sjögren syndrome (SjS). METHODS We had analyzed the development of cancer in 1300 consecutive patients fulfilling the 2002 SjS classification criteria. The baseline clinical and immunological characteristics and systemic activity (ESSDAI scores) were assessed at diagnosis as p...

Although biological therapy has shown promising clinical responses in many cancers including metastatic melanoma, only a subset of patients has shown marked regression of lesions. In most patients, systemic administration of biological therapies with cytokines is associated with severe toxicities. Schwager et al., in this issue of Journal of Investigative Dermatology, have examined the role of ...

Abstract Purpose of Review Triple-negative breast cancer (TNBC) represents about 15–20% all cancers and often presents as an aggressive with poor prognosis compared to other forms cancer. This article will review the clinical manifestations, imaging features, pathology correlation, treatment management, TNBC. Recent Findings While mammography ultrasound can be used diagnose TNBC, MRI is most ac...

Introduction: The SCAN gynaecological cancers systemic therapy workgroup aimed to develop Singapore Cancer Network (SCAN) clinical practice guidelines for front-line systemic therapy of advanced epithelial ovarian cancer. Materials and Methods: The workgroup utilised a modifi ed ADAPTE process to calibrate high quality international evidence-based clinical practice guidelines to our local setti...