Oxidative damage to DNA is thought to play a significant role in mutagenesis, aging, and cancer. Sensitivity to oxidative DNA damage and DNA repair efficiency were examined using a series of human breast epithelial cell lines-MCF-10A, MCF-10AT, and MCF-10ATG3B-with progressively elevated Ras protein. Breast epithelial cells were treated with H2O2, in the absence and presence of the DNA-repair i...

Description The package implements the statistical theory of L-moments in R including L-moment estimation, probability-weighted moment estimation, parameter estimation for numerous familiar and not-so-familiar distributions, and L-moment estimation for the same distributions from the parameters. L-moments are derived from the expectations of order statistics and are linear with respect to the p...

cydonia oblonga mill. (quince) is a member of rosaceae family that widely used in iranian traditional medicine. this plant contains large amounts of flavonoids and polyphenols and has antioxidant, antibacterial, free radical scavenging and several other effects. this study was undertaken to evaluate the genotoxic and genoprotective effects of hydroalcoholic and polyphenolic extracts of quince o...

Ricinus communis commonly known as castor oil plant is used in Indian indigenous medicinal system of Ayurveda to treat various diseases like sleeping disorders (insomnia), gall bladder pain, headache, backache, expulsion placenta and arthritis. The present study deals with the genotoxic effects silver nanoparticles leaves seeds aqueous extracts human lymphocytes Escherichia coli by comet assay....

PURPOSE The more common approach to comet assay studies with cancer patients involves indirect measurement of the effect of antineoplastic drug or radiation regimen by assessing DNA damage in surrogate cells, such as peripheral blood lymphocytes of cancer patients, to predict how tumor cells may be affected. The aim of the present study was to compare the capability of different cells isolated ...

The mechanisms whereby bile acid reflux may accelerate the progression from Barrett's esophagus (BE) to esophageal adenocarcinoma (EA) are not fully understood. In this study we found that bile acid taurodeoxycholic acid (TDCA) significantly increased the tail moment (TM) and histone H2AX phosphorylation in FLO-1 EA cells, an increase which was significantly decreased by knockdown of TGR5. Over...

Using the tail index of returns on US equities as a summary measure of extreme behaviour, we examine changes in the equity markets surrounding the development of program trading for portfolio insurance, the crash of 1987, and the subsequent introduction of circuit breakers and other changes in market architecture. Recentlydeveloped tests for the null of constancy of the tail index, versus the a...

We consider risk-neutral returns and show how their tail asymptotics translate directly to asymptotics of the implied volatility smile, thereby sharpening Roger Lee’s celebrated moment formula. The theory of regular variation provides the ideal mathematical framework to formulate and prove such results. The practical value of our formulae comes from the vast literature on tail asymptotics and o...