The anti-allodynic effect of NMDA receptor antagonist and acupuncture treatments were explored through spinal p35 regulation of diabetic neuropathic rat. We evaluated the change over time of p35/p25 protein levels in the spinal cord compared with behavioral responses to thermal and mechanical stimulation in streptozotocin (STZ)-induced diabetic rats. Additionally, we studied p35 expression when...

Neurons responding to innocuous thermal stimulation of the anterior tongue were newly identified in the dorsal margin of the trigeminal principal nucleus (PV). Connections of the dorsal margin of the PV were neuroanatomically identified using wheat germ agglutinin-conjugated horseradish peroxidase (WGA-HRP) with electrophysiological techniques. Injection of WGA-HRP into the dorsal margin of the...

High-frequency electrical stimulation (HFS) of the human skin induces an increase in both mechanical and heat pain sensitivity in the surrounding unconditioned skin. The aim of this study was to investigate the effect of HFS on the intensity of perception and brain responses elicited by the selective activation of C fibers. HFS was applied to the ventral forearm of 15 healthy volunteers. Temper...