نتایج جستجو برای: tpa therapy
تعداد نتایج: 659243 فیلتر نتایج به سال:
Radiation enteropathy is a common complication in cancer patients following radiation therapy. Thus, there is a need for agents that can protect the intestinal epithelium against radiation. 12-O-tetradecanoylphorbol-13-acetate (TPA) has been shown to induce differentiation and/or apoptosis in multiple cell lines and primary cells. In the current report, we studied the function of TPA in radiati...
Significant shortcomings in clinical thrombolysis efficiencies and arterial recanalization rates still exist to date necessitating the development of additional thrombolysis-enhancing technologies. For example, to improve tPA-induced systemic clot lysis several supplementary treatment methods have been proposed, among them ultrasound-enhanced tissue plasminogen activator (tPA) thrombolysis whic...
Objective: The aim of this study is to retrospectively collect the data 95 patients with ischemic stroke who received intravenous (IV) tissue plasminogen activator (tPA) therapy between 2015 and 2019 in our clinic, present experiences clinic. 
 Method: patients, applied clinic diagnosis acute 2019, thrombolytic therapy, were reviewed retrospectively. General socio-demographic data, clinica...
Case Report A 70-year-old man who did not take any regular medication presented at the emergency room 73 min after the sudden onset of an impaired level of consciousness, dysarthria, left-sided hemiparesis and left-sided neglect. His NIHSS (National Institutes of Health Stroke Scale) score was 16. His blood pressure was 121/87 and his laboratory data showed glucose 126 mg/dl, a platelet count o...
Intravenous thrombolysis with recombinant tissue-type plasminogen activator (intravenous tPA) has been the only approved therapy for acute ischemic stroke for almost 20 years. Recently, a new era in acute stroke treatment has begun: 5 randomized controlled trials have consistently shown that endovascular clot retrieval in addition to best medical treatment (±intravenous tPA) improves outcome in...
BACKGROUND AND PURPOSE We sought to measure the overall rate of usage of tissue-type plasminogen activator (tPA) for ischemic stroke at academic medical centers, and to determine whether ethnicity was associated with usage. METHODS Between June and December 1999, 42 academic medical centers in the United States each identified 30 consecutive ischemic stroke cases. Medical records were reviewe...
Peritoneal fibrosis (PF) is an important complication of peritoneal dialysis therapy. The present study was performed to examine the mechanisms of PF in view of the plasminogen activator (PA)/plasmin/matrix metalloproteinase (MMP) cascade. PF was induced in tissue-type PA (tPA) deficient mice and wild-type mice by intraperitoneal injection of chlorhexidine gluconate. Mice were killed on day 21,...
امروزه کشاورزی مولکولی پتانسیل بالایی در تولید نامحدود واکسنها، آنتیبادیها، پروتئینهای دارویی، عامل های رشد و آنزیمها دارد. فعال کننده پلاسمینوژن بافتی (tpa)، سرین پروتئازی است که نقش مهمی در سیستم فیبرینولیتیک و انحلال لخته های فیبرین در انسان دارد و به طور عمده در کبد و جداره رگ های خونی سنتز می شود. در بین سیستمهای موجود انتقال ژن، انتقال توسط اگروباکتریوم به عنوان یک روش مناسب برای الحاق پا...
BACKGROUND Clinical studies using ultrasound at diagnostic frequencies in transcranial Doppler devices provided encouraging results in enhancing thrombolysis with tissue plasminogen activator (tPA) in acute stroke. Low-frequency ultrasound does not require complex positioning procedures, penetrates through the skull better, and has been demonstrated to accelerate thrombolysis with tPA in animal...
BACKGROUND AND PURPOSE Insulin-like growth factor (IGF)-1 has potent neuroprotective properties. We investigated the effects of intravenous administration of tissue plasminogen activator (tPA) on serum levels of IGF-1 and IGF-binding protein (IGFBP)-3 in patients with acute ischemic stroke. METHODS Serum levels of total IGF-1, free IGF-1, and IGFBP-3 were measured by radioimmunoassay in 10 pa...
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