Monoclonal antibodies prepared by somatic cell hybridization techniques are ideal tools for the discrimination of cellular antigens and are beginning to reveal qualitative and quantitative differences in the antigenic composition of normal and malignant cells. Because these reagents are homogeneous in nature, recognize specific antigenic determinants, and can be mass produced, monoclonal antibo...

Mesothelin (MSLN) is a glycophosphatidylinositol (GPI)-linked cell surface protein highly expressed in several types of malignant tumors sometimes in association with increased tumor aggressiveness and poor clinical outcome. In the present study, 1562 tumors were immunohistochemically analyzed for mesothelin expression using two different types of mouse monoclonal antibodies (5B2 and MN-1) to d...

The registration of new drugs significantly expands the possibilities hematologists and oncologists in treatment tumors lymphoid tissue. cost monoclonal antibodies, inhibitors various signaling pathways immune checkpoints disproportionately exceeds direct "classical" programs combined cytostatic therapy. regimens included National Clinical Guidelines remain basis first-line therapy, are with ag...

We describe the properties of two monoclonal antibodies produced to a synthetic peptide consisting of residues 985 to 996 from the cytoplasmic domain of the epidermal growth factor (EGF) receptor. We have examined a group of ten human tumors including cervical, ovarian, and vulval carcinomas for expression of EGF receptors by immunohistological staining using one of these antibodies and another...

Monoclonal antibodies have been generated against disrupted mammary tumor viruses isolated from Mus musculus, Mus cervicolor, and Mus cookii. Monoclonal antibodies directed against the M.W. 36,000 external glycoproteins of these viruses demonstrate the presence of multiple epitopes, i.e., distinct antigenic determinants, within these glycoproteins. These epitopes represent type, group, and inte...

The purpose of this work was to investigate whether sucrase-isomaltase from enterocyte-like differentiated human colon carcinoma cell lines carries blood group antigens of the ABH system. Six cultured lines of blood group A (HT-29, SW-480, Co-115) or O phenotype (Caco-2, HRT-18, HCT-8R) were studied. Only HT-29 cells grown in the absence of glucose (HT-29 Glc-) and Caco-2 cells express an enter...

An ideal treatment modality for metastasizing tumors should eradicate the primary tumor and elicit a systemic, tumor-selective response leading to elimination of metastases and long-term tumor resistance. Also, it should be induced by local treatment at the primary site, to limit adverse systemic effects. A new method for treating metastatic tumors which utilizes a combination of a near-infrare...

Phosphatidylserine (PS) is a phospholipid normally residing in the inner leaflet of the plasma membrane and becomes exposed on tumor vascular endothelial cells (ECs) and tumor cells, and exposure is enhanced in response to chemotherapy, irradiation and oxidative stresses in the tumor microenvironment. PS exposure in tumors promotes an immunosuppressive microenvironment which includes the recrui...

OX40 agonist antibodies have shown promising preclinical activity but limited clinical success thus far, likely owing to a suboptimal pharmacological profile, inappropriate dosing regimen, and lack of biomarker strategy for patient selection. HFB301001 is novel human IgG1 antibody that binds unique epitope on allowing agonistic without competing with the endogenous ligand, inducing minimal down...

Malignant melanoma is one of the most important tumors in dogs and highly metastatic aggressive disease. In recent years, molecular knowledge regarding canine has increased, some chromosomal imbalances tyrosine kinase pathways have been identified to be dysregulated. Mxoreover, an immunogenic tumor that provides opportunities administer immunotherapy patient. Podoplanin chondroitin sulfate prot...