Urea transport (UT) proteins facilitate the concentration of urine by the kidney, suggesting that inhibition of these proteins could have therapeutic use as a diuretic strategy. We screened 100,000 compounds for UT-B inhibition using an optical assay based on the hypotonic lysis of acetamide-loaded mouse erythrocytes. We identified a class of triazolothienopyrimidine UT-B inhibitors; the most p...

Aging is commonly associated with defective urine-concentrating ability. The present study examined how the kidney and the brain of senescent (30-mo-old) female WAG/Rij rats respond to dehydration induced by 2 days of water deprivation in terms of urea transporter (UT) regulation. In euhydrated situation, senescent rats exhibited similar vasopressin plasma level but lower urine osmolality and p...

Addresses: *Department of Oncological Sciences, Huntsman Cancer Institute, Salt Lake City, UT 84112, USA. †Lineberger Comprehensive Cancer Center and Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA. ‡ARUP Laboratories Inc., Salt Lake City, UT 84108, USA. §Department of Pathology, University of Utah, Salt Lake City, UT 84112, USA. ¶Department of Mathematics, Univ...

205. Antimicrobial Stewardship Knowledge, Attitudes and Practices among Healthcare Professionals in Utah Whitney R. Buckel, PharmD; Adam L. Hersh, MD, PhD; Andrew Pavia, MD, FIDSA, FSHEA; Peter S. Jones, MSLS; Josh Caraccio, PharmD; Dustin Waters, PharmD, BCPS; Ashli Owen-Smith, PhD; Edward Stenehjem, MD MSc; Intermountain Medical Center, Murray, UT; University of Utah School of Medicine, Salt ...

For any finite horizon Sinai billiard map T on the two-torus, we find t_*>1 such that for each t in (0,t_*) there exists a unique equilibrium state $\mu_t$ $- t\log J^uT$, and is T-adapted. (In particular, SRB measure \log J^uT$.) We show exponentially mixing Holder observables, pressure function $P(t)=\sup_\mu \{h_\mu -\int J^uT d \mu\}$ analytic (0,t_*). In addition, P(t) strictly convex if o...

The UT-A1 urea transporter plays a critical role in the production of concentrated urine. Both vasopressin and hypertonicity increase urea permeability in rat terminal inner medullary collecting ducts (IMCD). Each agonist independently increases UT-A1 phosphorylation and apical plasma membrane accumulation. Vasopressin activates PKA and phosphorylates UT-A1 at serines 486 and 499. Hypertonicity...

Background The pathogenesis of endotoxemic tubular dys-function with failure in urine concentration is poorly understood. Urea plays an important role in the urinary concentrating mechanism and expression of the urea transporters UT-A1, UT-A2, UT-A3, UT-A4 and UT-B is essential for tubular urea reabsorption. The present study attempts to assess the regulation of renal urea transporters during s...

Mammalian urea transporters (UTs), UT-A and UT-B, are best known for their role in urine concentration. UT-B is especially distributed in multiple extrarenal tissues with abundant expression in vascular endothelium, but little is known about its role in vascular function. The present study investigated the physiological significance of UT-B in regulating vasorelaxations and blood pressure. UT-B...