In this paper, using the hyperbolic uniform spline of order 4 we develop the classes of methods for the numerical solution of second order boundary value problems (2VBP) with Dirichlet, Neumann and Cauchy types boundary conditions. The second derivativeis approximated by the three-point central difference scheme. The approximate results, obtained by the proposed method, confirm theconvergence o...

BACKGROUND Several organizations have developed frameworks to systematically assess the value of new drugs. OBJECTIVE To evaluate the convergent validity and interrater reliability of 4 value frameworks to understand the extent to which these tools can facilitate value-based treatment decisions in oncology. METHODS Eight panelists used the American Society of Clinical Oncology (ASCO), Europ...

32 Normative theories posit that value-based decision-making is context33 independent. However, decisions between two high-value options can be sub-optimally 34 biased by the introduction of a third low-value option. This context-dependent 35 modulation is consistent with the divisive normalization of the value of each stimulus by 36 the total value of all stimuli. In addition, an independent l...

Toll like receptors (TLRs) with a myeloid differentiation antigen (CD14) recognize and bind various structures from invading microbes and then trigger cell activation. They initiate a variety of effectors' functions, including cytokine secretion, proliferation, co-stimulation or phagocyte maturation. The aim of this study was to evaluate Toll-like receptor 4 (TLR4) and CD14 expression in childr...