A role of IL-18 in the induction of gastric lesions by water immersion and restraint stress (WRS) was investigated. When wild-type BALB/c mice were exposed to WRS, levels of IL-18 in the serum and stomach increased rapidly with the development of acute gastric lesions. In IL-18-deficient mice [IL-18 knockout (KO) mice] similarly exposed to WRS, no gastric lesions were observed, but the administ...

The present study aims to distinguish the effect of tocotrienol on an important gastric protective factor, prostaglandin E2 (PGE2), in stress-induced gastric injury. Twenty-eight Wistar rats were divided into four groups of seven rats each. Two control groups were fed commercial rat diet, and two treatment groups were fed the same diet but with additional dose of omeprazole (20 mg/kg) or tocotr...

Objective: To investigate the neuroprotective and antioxidant effects of leaves aqueous extract Moringa oleifera (MW) in chronic stress mouse models.
 Methods: Water immersion restraint for 16 d to obtain a model animal. flour dissolved Aquades, dose 800 mg/kg 23 d, Stress+MOW group. Fluoxetine aquades at 18 BW group+Fluoxetine. Aquades were given normal mice (group N), under conditions (c...

Objective: To evaluate the gastroprotective effects of β 3 -adrenoceptor agonists CGP 12177A and SR 58611A, on water immersion plus restraint stress (WIRS)-induced gastric ulceration in rats. Material and Methods: Drugs were administered (5, 10 and 15 mg/kg, p.o. ) 30 min prior to the ulcerogenic procedure. Ulcer index and the score for intensity of intraluminal bleeding were determined. Gastri...

AIMS Vasopressin (AVP) and oxytocin (OT) are considered to be related to gastric functions and the regulation of stress response. The present study was to study the role of vasopressinergic and oxytocinergic neurons during the restraint water-immersion stress. METHODS Ten male Wistar rats were divided into two groups, control and RWIS for 1h. The brain sections were treated with a dual immuno...

adrenal weight was generally enhanced by stress in all deitary groups, and particularly tended to be greater in the OLI and PSC groups than in the other tyvo. The plasma certicosterone concentration increased immediately after stressing (Stress-1), but approached the leyel of the rats with no stress (No stress) 2 h after releasing the stress load (Stress-2) in all groups. The enhancement of cor...