OBJECTIVES Total white blood cells (WBCs) decrease slightly in the elderly. In response to an acute infection, the number of WBCs increases and in sepsis, the increase is very dramatic. There are some reports about the effects of increased number of WBCs as a predisposing factor of bacteremia. An association between neutrophilia and eucopenia and increased mortality rate in the elderly has also...

Atherosclerosis develops at regions of the arterial tree exposed to disturbed flow. The early stage of atherogenesis involves the adhesion of leukocytes (white blood cells [WBCs]) to and their transmigration across endothelial cells (ECs), which are located in close proximity to smooth muscle cells (SMCs). We investigated the effects of EC/SMC coculture and disturbed flow on the adhesion and tr...

An integrated nano-electromechanical chip (NELMEC) has been developed for the label-free distinguishing of both epithelial and mesenchymal circulating tumor cells (ECTCs and MCTCs, respectively) from white blood cells (WBCs). This nanoelectronic microfluidic chip fabricated by silicon micromachining can trap large single cells (>12 µm) at the opening of the analysis microchannel arrays. The nat...

The extraction of virological markers in white blood cells (WBCs) from whole blood--without reagents, electricity, or instruments--is the most important first step for diagnostic testing of infectious diseases in resource-limited settings. Here we develop an integrated microfluidic chip that continuously separates WBCs from whole blood and mechanically ruptures them to extract intracellular pro...

OBJECTIVES To characterize glucocorticoid receptor expression in peripheral WBCs of critically ill children using flow cytometry. DESIGN Prospective observational cohort. SETTING A university-affiliated, tertiary PICU. PATIENTS Fifty-two critically ill children. INTERVENTIONS Samples collected for measurement of glucocorticoid receptor expression and parallel cortisol levels. MEASUREM...

This paper describes the design and implementation of the advertisement data management and corresponding intelligent application for use in wireless billboard channels (WBCs) services in the emerging ubiquitous consumer wireless world (UCWW). Running at the application enabler sub-layer of a WBC service provider (WBC-SP)’s node the advertisement data is formatted by using the abstract syntax n...

The current work presents a novel microfluidic approach, allowing full separation of blood cells. approach relies on using polydimethylsiloxane serpentine microchannel equipped with series electrodes, providing two zones. proposed design exploits the unique configuration channel along inherent difference in dielectric properties three kinds cells to achieve size-based sorting. platelets (PLTs) ...

Formalin-fixed, paraffin-embedded tumors (FFPETs) are a valuable source of DNA for genotype association studies and are often the only germline DNA resource from cancer clinical trials. The anti-estrogen tamoxifen is metabolized into endoxifen by CYP2D6, leading to the hypothesis that patients with certain CYP2D6 genotypes may not receive benefit because of their inability to activate the drug....

This study provides a global, detailed, and complete energy-saving map of strong ocean currents from the absolute geostrophic velocities calculated from satellite altimetry data, with the focus on the strong Western Boundary Currents (WBCs) in the global ocean. Theoretically, the WBCs with speeds of 2–3 knots can reduce fuel consumption by 25–50% for vessels at a sailing speed of 6 knots. The f...

Background: Early diagnosis is paramount to the treatment of neonatal infections. Nucleated red blood cells (NRBCs) are immature erythrocytes that increase in number due to stress and hypoxia. This study was conducted to determine NRBC count in the peripheral blood and examine its significance as a marker of neonatal infection. Methods: This case-control study was conducted on 154 infants (78 ...