نتایج جستجو برای: wilms tumor gene 1
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ABSTRACT: DRASH Syndrome is a rare congenital disorder,and the triad of drash syndrome are progressive renal insufficiency ,male pseudohermaphroditism & Wilms tumor .All of the reported cases were sporadic and autosomal dominant inheritance was suspected in some references. We diagnosed a 32- month child with this syndrome in IRAN in 1993. He was presented with wilms tumor and also had male p...
PURPOSE The most well established molecular markers of poor outcome in Wilms' tumor are loss of heterozygosity at chromosomes 1p and/or 16q, although to date no specific genes at these loci have been identified. We have previously shown a link between genomic gain of chromosome 1q and tumor relapse and sought to further elucidate the role of genes on 1q in treatment failure. EXPERIMENTAL DESI...
increment. it is categorized based on genetic aberrations. some of these genetic disorders can determine minimal residual diseases (mrd) and prognosis of aml patients. wilms tumor (wt1) over expression is found in aml patients. the aim of this study was to determine the frequency of wt1 over expression in aml pediatric cases in north -east of iran. materials and methods: this retrospective stud...
OBJECTIVE The current study was undertaken to explore the clinical and prognostic value of phosphatase of regenerating liver-3 (PRL-3) expression in Wilms' tumor. METHODS Seventy-six patients with Wilms' tumor in Qilu Hospital from January 2003 to July 2009 were enrolled in the study. Protein expression level of PRL-3 was examined by immunohistochemical staining, and the correlation between P...
The Wilms’ tumor suppressor gene (WT1) is a transcription factor that plays a major role in development of the gonads and kidneys. It is expressed even earlier than sexdetermining region of the Y chromosome in the urogenital ridge from which the gonads and kidneys are derived. WT1 mutations will impair gonadal and urinary tract development and have been demonstrated to cause syndromes of WAGR, ...
The Wilms tumor-suppressor gene, WT1, plays a key role in urogenital development, and WT1 dysfunction is implicated in both neoplastic (Wilms tumor, mesothelioma, leukemias, and breast cancer) and nonneoplastic (glomerulosclerosis) disease. The analysis of diseases linked specifically with WT1 mutations, such as Denys-Drash syndrome (DDS), can provide valuable insight concerning the role of WT1...
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