OBJECTIVE Impaired wound healing in diabetes is associated with decreased nitric oxide (NO) bioavailability in wound tissue. We hypothesized azelnidipine (AZL), a new calcium channel blocker with antioxidant properties, would enhance wound healing in streptozotocin-induced diabetic rats by restoring NO synthesis. METHODS Twelve male rats were taken as non-diabetic group. Twenty four rats were...

Background - The growing prevalence and incidence of nonhealing acute and chronic wounds is a worrying concern. A major challenge is the lack of united services aimed at addressing the complex needs of individuals with wounds. However, the WHO argues that interprofessional collaboration in education and practice is key to providing the best patient care, enhancing clinical and health-related ou...

Background: The application of mesenchymal stem cells in the healing of chronic wounds is one of the most challenging issues in cell therapy. The present study investigated the efficacy of intradermal injection of umbilical cord Wharton's Jelly-derived mesenchymal stem cells in diabetic wound healing using ultrasound imaging in an animal model. Methods: During this experimental laboratory stud...

Contribution and role of a pyramid/square box on the wound healing suppressant effect of dexamethasone was studied in rats of either sex using excision wound model to record the wound contraction rate and epithelization period. The results showed enhanced wound contraction rate and decreased epithelization period in the pyramid-exposed rats as compared to controls. Thus, it appears that pyramid...

healing of skin wound is a multi-factorial and complex process. proper treatment of diabetic wounds is still a major clinical challenge. although diabetes mellitus can occur in ruminants, healing of wounds in diabetic ruminants has not yet been investigated. the aim of this study was to evaluate healing of ovine excisional diabetic wound model. eight 4-month-old iranian makoui wethers were equa...

Considering the increasing incidence of chronic wounds and severe wound infections, effective drug delivery to wounded skin is of high importance. The rational development of novel therapeutic systems requires appropriate in vitro testing methodologies. In this context, suitable and reliable in vitro models simulating human wounds and advanced analytical techniques for precise wound characteriz...

conclusions the designed safe irrigator syringe seems to be applicable in wound irrigation and superior to the conventional devices regarding efficacy and user comfort. results all of the interns stated that the new device is quite applicable for wound washing and is easy to handle. nine interns believed that safe irrigator syringe is superior to the conventional devices regarding efficacy and ...