The nuclear pore complex (NPC) is the portal for bidirectional transportation of cargos between the nucleus and the cytoplasm. While most of the structural elements of the NPC, i.e. nucleoporins (Nups), are well characterized, the exact transport mechanism is still under much debate. Many of the functional Nups are rich in phenylalanine-glycine (FG) repeats and are believed to play the key role...

Despite the complete imprint of a visual scene on the retina, the brain selects particular items for further processing. However, there is considerable debate about when and where the first attentional effects take hold in the cortex. We examined the timing of face specificity and attentional influences in the primary/secondary visual cortex (V1/V2) and in the fusiform gyrus (FG) in two experim...

The 62 kDa FG repeat domain of the nucleoporin Nsp1p forms a hydrogel-based, sieve-like permeability barrier that excludes inert macromolecules but allows rapid entry of nuclear transport receptors (NTRs). We found that the N-terminal part of this domain, which is characterized by Asn-rich inter-FG spacers, forms a tough hydrogel. The C-terminal part comprises charged inter-FG spacers, shows lo...

This study was undertaken to identify genetic polymorphisms that are associated with the risk of an elevated fasting glucose (FG) level using genome-wide analyses. We explored a quantitative trait locus (QTL) for FG level in a genome-wide study from a Korean twin-family cohort (the Healthy Twin Study) using a combined linkage and family-based association analysis approach. We investigated 1,754...

In the desert locust, Schistocerca gregaria, the frontal ganglion (FG) plays a key role in control of foregut movements, and constitutes a source of innervation to the foregut dilator muscles. In this work we studied the generation and characteristics of FG motor outputs in two distinct and fundamental behaviours: feeding and moulting. The FG motor pattern was found to be complex, and strongly ...

The present study reports on fibrinogen (Fg) binding of Staphylococcus epidermidis. Adhesion of different S. epidermidis strains to immobilized Fg was found to vary significantly between different strains, and the component responsible was found to be proteinaceous in nature. To further characterize the Fg-binding activity, a shotgun phage display library covering the S. epidermidis chromosome ...

This study examined the effects of storage conditions such as time course, temperature, fluorescent light, and darkness on the components and antibacterial activity of formalin guaiacol (FG) used in endodontic treatment. We measured the quantities of formaldehyde and guaiacol in FG and antibacterial activities against Staphylococcus aureus, Porphyromonas gingivalis, and Porphyromonas endodontal...

curacies within navigation software was investigated. Novel hybrid tracker configurations included use of the Window FG with infrared and/or video-based trackers. Results The fiducial registration error (FRE) between fiducials on the vertical phantom and divot targets was (1.12 ± 0.39), (1.19 ± 0.59), and (1.30 ± 0.91) mm in (x, y, z) directions for the Window FG, respectively, and (1.49 ± 0.63...

In this study, the mechanical buckling response of refined hyperbolic shear deformable (FG) functionally graded nanobeams embedded in an elastic foundation is investigated based on the refined hyperbolic shear deformation theory. Material properties of the FG nanobeam change continuously in the thickness direction based on the power-law model. To capture small size effects, Eringen’s nonlocal e...

Abstract Nuclear pore complexes (NPCs) regulate all molecular transport between the nucleus and cytoplasm in eukaryotic cells. Intrinsically disordered Phe-Gly nucleoporins (FG-Nups) line central conduit of NPCs to impart a selective barrier where large proteins are excluded unless bound receptor (karyopherin; Kap). Here, we assess “Kap-centric” NPC models, which postulate that Kaps participate...