The study attempted to clarify the role of total antioxidant capacity of seminal plasma (SP-TAC) on boar sperm survival and fertility after artificial insemination (AI). SP-TAC differed (P < 0.001) among boars (n° = 15) and, to a lesser degree, among ejaculates within male (4 ejaculates/boar). SP-TAC also differed (P < 0.001) among ejaculate fractions (43 ejaculates and 3 fractions per ejaculat...

BACKGROUND The ubiquitin-proteasome system (UPS) is an important pathway of proteolysis in pathologic hypertrophic cardiomyocytes. We hypothesize that MG132, a proteasome inhibitor, might prevent hypertrophic cardiomyopathy (CMP) by blocking the UPS. Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and androgen receptor (AR) have been reported to be mediators of CMP and he...

The Two-Way Task: Run1: TAC-M, TS-M, and Tri-BM Run2: TAC-M, TS-M, and BoW-BM Run3: TAC-M, TS-M, NE-M, & Tri-BM, BoW-BM The Three-Way Task: Run1: TAC-M, TS-M, and Tri-BM, BoWBM Run2: TAC-M, TS-M, NE-M (partial), and Tri-BM, BoW-BM Run3: TAC-M, TS-M, NE-M, and Tri-BM, BoW-BM From Two-Way to Three-Way: If BoW-BM=YES & Tri-BM=NO then CONTRADICTION If BoW-BM=YES & Tri-BM=YES then ENTAILMENT Others ...

Current guidelines do not mention tacrolimus (TAC) as a treatment option and no consensus has been reported on the role of TAC in lupus nephritis (LN). The present study aimed to guide clinical judgement on the use of TAC in patients with LN. A meta-analysis was performed for clinical studies investigating TAC regimens in LN on the basis of treatment target (induction or maintenance), concomita...

BACKGROUND This study investigated the effect of St John's wort (SJW) extract on the pharmacokinetics of the immunosuppressants tacrolimus (TAC) and mycophenolic acid (MPA). METHODS Ten stable renal transplant patients received 600 mg SJW extract for 14 days in addition to their regular regimen of TAC and mycophenolate mofetil. RESULTS Dose-corrected AUC((0-12)) of TAC decreased significant...

OBJECTIVE Treatment of severe ulcerative colitis (UC) is challenging. Although the efficacy of tacrolimus (TAC) and infliximab (IFX) have been evaluated in patients with severe UC, the safety and efficacy levels of sequential therapies (TAC→IFX/IFX→TAC) in these patients remain unclear. The aim of this study was to assess short-term and long-term outcomes in patients with severe UC treated with...

Background. This study investigated the effect of St John’s wort (SJW) extract on the pharmacokinetics of the immunosuppressants tacrolimus (TAC) and mycophenolic acid (MPA). Methods. Ten stable renal transplant patients received 600 mg SJW extract for 14 days in addition to their regular regimen of TAC and mycophenolate mofetil. Results. Dose-corrected AUC(0–12) of TAC decreased significantly ...