نتایج جستجو برای: ژن dnmt1
تعداد نتایج: 17431 فیلتر نتایج به سال:
Bortezomib reversibly inhibits 26S proteasomal degradation, interferes with NF-kappaB, and exhibits antitumor activity in human malignancies. Zinc finger protein Sp1 transactivates DNMT1 gene in mice and is functionally regulated through protein abundance, posttranslational modifications (ie, ubiquitination), or interaction with other transcription factors (ie, NF-kappaB). We hypothesize that i...
Dnmt1 is the predominant DNA methyltransferase (MTase) in mammals. The C-terminal domain of Dnmt1 clearly shares sequence similarity with many prokaryotic 5mC methyltransferases, and had been proposed to be sufficient for catalytic activity. We show here by deletion analysis that the C-terminal domain alone is not sufficient for methylating activity, but that a large part of the N-terminal doma...
سرطان یکی از مهمترین عوامل مرگ و میر در جهان است؛ لذا توجه به پیشگیری و درمان آن از اهمیت زیادی برخوردار است. تغییرات ناهنجار اپی ژنتیک شامل متیلاسیون dna و تغییرات هیستونی نقش مهمی در سرطان زایی دارند. از آن جایی که این تغییرات نسبت به تغییرات ژنتیکی برگشت پذیرند، بالقوه درمان اپی ژنتیکی در برگرداندن برخی از این تغییرات ناهنجار کارا می باشد. آنالیز ترانسکریپتوم حاکی از رونویسی 90% ژنوم در یوکا...
STUDY QUESTION Is DNA methyltransferase 1 (DNMT1) dysfunction involved in epigenetic deregulation of placentae from embryos obtained by assisted reproduction technologies (ARTs)? SUMMARY ANSWER DNMT1 expression in growing placentae of in vitro produced (IVP) embryos is compromised and associated with pregnancy loss. WHAT IS KNOWN ALREADY DNMT1 maintains the methylation profile of genes duri...
DNA methylation and histone modifications are key epigenetic regulators of gene expression, and tight connections are known between the two. DNA methyltransferases are upregulated in several tumors and aberrant DNA methylation profiles are a cancer hallmark. On the other hand, histone demethylases are upregulated in cancer cells. Previous work on ES cells has shown that the lysine demethylase K...
The transcription factor Oct4 plays a pivotal role for the development of mouse preimplantation embryo, and DNA methyltransferase 1 (Dnmt1) maintains the changes of DNA methylation during mammalian early embryonic development. However, little is known of the role of Oct4 in DNA methylation in mouse. In the present study, Kunming white mice were used as an animal model to elucidate the correlati...
X chromosome inactivation (XCI) in human and mice involves XIST/Xist gene expression from the inactive X (Xi) and repression from the active X (Xa). Repression of the XIST/Xist gene on the Xa has been associated with methylation of its 5' region. In mice, Dnmt1 has been shown to be involved in the methylation and transcriptional repression of Xist on Xa. We examined maintenance of XIST gene rep...
In this study, we demonstrated that STAT3, a well-characterized transcription factor expressed in continuously activated oncogenic form in the large spectrum of cancer types, induces in malignant T lymphocytes the expression of DNMT1, the key effector of epigenetic gene silencing. STAT3 binds in vitro to 2 STAT3 SIE/GAS-binding sites identified in promoter 1 and enhancer 1 of the DNMT1 gene. ST...
RGS10 is an important regulator of cell survival and chemoresistance in ovarian cancer. We recently showed that RGS10 transcript expression is suppressed during acquired chemoresistance in ovarian cancer. The suppression of RGS10 is due to DNA hypermethylation and histone deacetylation, two important mechanisms that contribute to silencing of tumor suppressor genes during cancer progression. He...
β-elemene, a compound derived from Rhizoma zedoariae, is a promising new plant-derived drug with broad-spectrum anticancer activity. However, the underlying mechanism by which this agent inhibits human lung cancer cell growth has not been well elucidated. In this study, we showed that β-elemene inhibits human non-small cell lung carcinoma (NSCLC) cell growth, and increased phosphorylation of ER...
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