Insulin receptor substrate (IRS) is a key adapter protein mediating effects of insulin and insulin-like growth factors (IGF) in cells. IRS-1 member the family, which associated with tumor initiation progression. The aim study to determine level blood patients (n = 81) diabetes mellitus COVID-19. was determined enzyme-linked immunosorbent assay (ELISA) (Elabscience, USA). measurements were perfo...

Human-induced pluripotent stem cell- (iPSC-) derived insulin-producing cells (IPCs) can be used for islet cell transplantation into type 1 diabetic patients and as patient-specific the development of novel antidiabetic drugs. However, a method is needed to generate functional IPCs from iPSCs simplify protocol. We compared combinations small molecules that could induce differentiation definitive...

The cytokines IFN-?, interleukin IL-1?, and TNF-? each up regulate the expression of major histocompatibility complex (MHC) are therefore considered as inflammatory markers. present study aimed to measure serum levels in mice after induction diabetes with streptozotocin correlate their lipid glycaemic profiles. included 40 Swiss Albino (20 males 20 females), half male female groups were made di...

Background and Aims: Diabetes is one of the most important endocrine disrupters and is associated with various hormones, including those that can lead to diabetes. Glucocorticoid use may lead to insulin resistance. Dexamethasone is one of these glucocorticoid compounds. Glutamate dehydrogenase plays a key role in the production of glutamate in the secretion of insulin. Based on these hormonal i...

There is some report about the hypoglycemic effect of Juglans rejia L. leaf in alloxan induced diabetic rats and hypoglycemic effect of its fruit peel administered intra peritoneally. Thirty male Wistar rats divided into five groups, to evaluate the hypoglycemic and pancreas β-cells regenerative effects of oral methanolic extracts of leaf and fruit peel of walnut. Rats were made diabetic by int...