BACKGROUND AND PURPOSE We tested the hypothesis that inhibiting nitric oxide production either before or during transient focal ischemia affects early postischemic brain injury. METHODS Halothane-anesthetized cats underwent 1 hour of left middle cerebral artery occlusion plus 3 hours of reperfusion. Pretreatment groups received either intravenous N omega-nitro-L-arginine methyl ester (L-NAME;...

alstroemeria flower is one of the most important cut flowers in the world. some materials can increase longevity of cut flowers. the aim of this research was evaluating the effect of some chemical solutions on postharvest alstroemeria (cv. stratus) cut flowers. this experiment was conducted with two factors of sucrose at four concentrations, 0, 5, 10 and 15 g/l and salicylic acid (sa) at four c...

The slaughterhouse industry produces large amounts of highly polluted wastewater which needs to be treated before being discharged water. Thus, this work was conducted investigate the feasibility treating using combined chemical coagulation and electro-Fenton methods. We studied effect process parameters such as polyaluminum chloride (PAC) concentration (25, 50, 75, 100 mg/L) for hydrogen perox...

Background: It remains unclear whether the mean vancomycin trough concentration (VTC) derived from entire course of therapy is potential benefit for critically ill patients. This study was conducted to explore association between serum VTC and mortality in intensive care units (ICUs). Methods: 3,603 adult patients with two or more records after receiving treatment eICU Collaborative Research Da...

I describe a gas-chromatographic procedure involving a nitrogen detector for "free" (or "unbound") phenytoin in the concentration range 0.2-4.0 mg/L in ultrafiltrates of plasma. The CV (n = 10) for the assay was 2.9% for a 0.49 mg/L concentration, 1.5% for 2.02 mg/L. The sensitivity was 0.05 mg/L. The ultrafiltration process ("Ultra-Free" filters) used to separate the free phenytoin fraction fr...

The purpose of this article is to assess the diagnostic accuracy of C-reactive protein (CRP) and white blood cell (WBC) count to discriminate between urgent and nonurgent conditions in patients with acute abdominal pain at the emergency department, thereby guiding the selection of patients for immediate diagnostic imaging.Data from 3 large published prospective cohort studies of patients with a...

Significant decreases in magnesium (Mg) concentration and alkaline phosphatase (ALP, EC 3.1.3.1) activity in serum were seen in patients after cardiac surgery with cardiopulmonary bypass (Group 1), as compared with non-cardiac-surgery patients after general anesthesia (Group 2) or only spinal anesthesia (Group 3). Mean changes for Mg and ALP by the first postoperative day, compared with pre-ope...

PURPOSE The aim of this study was to determine (i) the maximum tolerated dose (MTD) of liposomal doxorubicin (L-DOX) and paclitaxel (DP), (ii) the MTD of DP plus valspodar (DPV) and (iii) pharmacokinetic (PK) interactions of valspodar with L-DOX and paclitaxel. METHODS Twenty-three patients with metastatic cancers received DP, followed 4 weeks later by DPV. Dose levels of DP were (mg/m2 for L...