background: tissue iron deposition may disturb functions of the organs. in many diseases like thalassemia, the patients suffer from iron deposition in kidney and heart tissues. deferoxamine (df) is a synthetic iron chelator and silymarin (sm) is an antioxidant and also a candidate for iron chelating. this study was designed to investigate the effect of df and sm combination against kidney and h...

recent studies have reported that metal sulfide nanoparticles had potential adverse effects.  in this research, lead (ii) sulfide nanoparticles have been synthesized under different reaction conditions. scanning electron microscopy and x-ray diffraction were used to characterize the particle size and morphology. distribution, accumulation and toxic effects of nanoparticles on rats as a biologic...

In order to create Fe2O3 and Fe2O3·H2O nanoparticles, various polymers were used as dispersing agents, and the resulting effects on the dispersibility and nanoparticulation of the iron oxides were evaluated. It was revealed that not only the solution viscosity but also the molecular length of the polymers and the surface tension of the particles affected the dispersibility of Fe2O3 and Fe2O3·H2...

Effects of heavy metals on the dechlorination of carbon tetrachloride by iron nanoparticles were investigated in terms of reaction kinetics and product distribution using batch systems. Removal of heavy metals and the interaction between heavy metals and iron nanoparticles at the iron surface were also examined. It was found that Cu(II) enhanced the carbon tetrachloride dechlorination by iron n...

Nanostructures loaded on halloysite nanotubes (HNTs) have attracted global interest, because the nanotubular HNTs could extend the range of their potential applications. In this study, we fabricated a novel nanocomposite with hollow iron nanoparticles loaded on the surface of HNTs. The structure of the iron nanoparticles can be adjusted by ageing time. Owing to the increased remnant magnetizati...

Background and Aim: Iron oxide nanoparticles are used in fields related to nanotechnology including ecology, magnetic storage, imaging and medicinal purposes. Iron nanoparticles produce reactive oxygen species (Ros). These materials are able to cross the placenta. The aim of this study was to investigate toxic effect of iron oxide nanoparticles on fetal lung in mice. <br ...

transfusion in the treatment of thalassemia gives rise to iron deposits in many organs. since there are many obstacles in the use of deferoxamin (dfo) as an iron chelating agent, it is important to find another alternative therapy that can act as iron chelation. the study aims to compare the histopathological pictures of the heart and spleen in iron-induced rats after administration of dfo and ...

The purpose of this study was to synthesize biocompatible poly(2-hydroxyethyl aspartamide)-C16-iron oxide (PHEA-C16-iron oxide) nanoparticles and to evaluate their efficacy as a contrast agent for magnetic resonance imaging of lymph nodes. The PHEA-C16-iron oxide nanoparticles were synthesized by coprecipitation method. The core size of the PHEA-C16-iron oxide nanoparticles was about 5 to 7 nm,...

BACKGROUND Iron deficiency anaemia is common in patients with non-dialysis-dependent chronic kidney disease (NDD-CKD) and is often treated with oral or intravenous (IV) iron therapy. This trial compared the efficacy and safety of IV iron isomaltoside 1000 (Monofer®) and oral iron in NDD-CKD patients with renal-related anaemia. METHODS The trial was a Phase III open-label, comparative, multice...