To determine the roles of nitric oxide in glaucomatous injury and its regulation by δ-opioid-receptor activation, animals were treated with: 1) a selective inducible nitric oxide synthase (iNOS) inhibitor (aminoguanidine; AG; 25 mg/kg, i.p.); 2) δ-opioid-receptor agonist (SNC-121; 1 mg/kg, i.p.); or 3) with both drugs simultaneously for 7 days, once daily. The loss in retinal ganglion cell (RGC...

A new archaeal isolate has been reported that is capable of growing at up to 121 °C. This hyperthermophile, dubbed strain 121, grows chemoautotrophically using formate as an electron donor and Fe as an electron acceptor and is closely related to members of the archaeal genera Pyrodictium and Pyrobaculum. Although the reported maximum growth temperature of strain 121 is 8 °C higher than the prev...

activation of ErbB3 and to sensitize platinum-resistant cells to subsequent chemotherapy. Materials and Methods: Cisplatin-sensitive (A2780) and -resistant (A2780cis) ovarian cancer cell lines were acquired from ATCC. Primary ascites cells were isolated from advanced stage ovarian cancer patients who had undergone prior therapy. Cells were propagated in vitro and cell viability assays were perf...

PURPOSE We examined the signaling mechanisms involved in δ-opioid-receptor agonist, SNC-121-mediated attenuation of TNF-α-induced matrix metalloproteinase-2 (MMP-2) secretion from human optic nerve head (ONH) astrocytes. METHODS Human ONH astrocytes were treated with SNC-121 (1 μmol/L) for 15 minutes followed by TNF-α (25 ng/mL) treatment for 6 or 24 hours. Cells were pretreated with inhibito...

MHC class I-restricted CD8(+) T cells play an important role in protective immunity against mycobacteria. Previously, we showed that p113-121, derived from Mycobacterium leprae protein ML1419c, induced significant IFN-γ production by CD8(+) T cells in 90% of paucibacillary leprosy patients and in 80% of multibacillary patients' contacts, demonstrating induction of M. leprae-specific CD8(+) T ce...

We present the results of photometric measurements from images of the LMC cluster ESO 121-SC03 taken with the Advanced Camera for Surveys on the Hubble Space Telescope. Our resulting colour-magnitude diagram (CMD) reaches 3 magnitudes below the main-sequence turn-off, and represents by far the deepest observation of this cluster to date. We also present similar photometry from ACS imaging of th...