A series of polysubstituted 1,4-dihydropyridines (4a-i) were designed and developed using Ph-B(OH)2 catalyst. Further, compounds confirmed by various spectroscopic techniques. After that all studied for molecular docking against the human peroxidase enzyme (1PRX). Results revealed many exhibited low binding score. To get a reference from study, synthesized molecules evaluated in vitro antioxida...

Abstract The antiprotozoal activity of 1-benzyltetrahydropyridin-4-yliden iminium salts is reported. This paper describes the preparation a series analogs from dihydropyridines or dihydrothiopyrans as educts. new compounds were investigated for their against Plasmodium falciparum NF54, causative organism Malaria tropica and Trypanosoma brucei rhodesiense , Human African Trypanosomiasis (sleepin...

Nifedipine is a dihydropyridine calcium-channel blocker (CCB) introduced approximately 30 years ago for the prophylaxis of angina symptoms, and then later utilized as an anti-hypertensive agent. In the 1990s, several meta-analyses and a case-control study were published which raised concern regarding increased mortality and increased risk for myocardial infarction with short-acting nifedipine. ...

An ytterbium catalyzed formal [3+3] cycloaddition of cyclic enamines and ?,?-unsaturated ketones is reported. The reaction proceeds with a ‘head to tail’ regioselectivity through conjugate addition the enamine moiety followed by an amine-carbonyl condensation. In use chiral provided high degree stereoselectivity, driven possible balance between steric ?-stacking effects. resulting bicyclic 1,4-...

In the title compound, C(21)H(25)NO(4), the dihydropyridine ring adopts a flattened boat conformation. The N atom and the sp(3) C atom deviate in the same direction from the mean plane of the other four C atoms, by 0.269 (6) and 0.111 (6) Å, respectively. This mean plane is inclined to the 4-methoxy-phenyl ring by 87.3 (5)°. The cyclohexenone ring has a sofa conformation with the C atom bearing...

In the title compound, C(21)H(27)NO(5), the dihydropyridine ring adopts a boat conformation. The ethoxy-phenyl ring is oriented approximately perpendicular to the planar part of the dihydropyridine ring, making a dihedral angle of 89.45 (6)°. An intra-molecular C-H⋯O hydrogen bond generates an S(6) ring motif. In the crystal structure, neighbouring mol-ecules are linked into chains along the a ...

Objective(s) Calcium-channel blockers have an important role in the treatment of several cardiovascular disorders. Derivatives of 1, 4-dihydropyridine are one of the most potent calcium antagonists. In this study four novel ', 4-dihydropyridine calcium channel blockers were synthesized and their hypotensive properties were investigated in male rats. Materials and Methods Four 1, 4-dihydropyr...