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Hossein Hosseinzadeh

Pharmaceutical Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran

[ 1 ] - Preparation, Characterization and Evaluation of Sun Protective and Moisturizing Effects of Nanoliposomes Containing Safranal

Objective(s) The objective of this study was to prepare, characterize and evaluate the nanoliposomes containing safranal as a natural sunscreen and moisturizer factor. Materials and Methods The experimental formulations included homosalate reference, nanoliposomes containing 0.25, 0.5, 1, 2, 4 and 8% safranal and empty liposomes. The liposomes were prepared using fusion method and homogeniza...

[ 2 ] - Synthesis of Novel 4-[1-(4-fluorobenzyl)-5-imidazolyl] Dihydropyridines and Studying their Effects on Rat Blood Pressure

Objective(s) Calcium-channel blockers have an important role in the treatment of several cardiovascular disorders. Derivatives of 1, 4-dihydropyridine are one of the most potent calcium antagonists. In this study four novel ', 4-dihydropyridine calcium channel blockers were synthesized and their hypotensive properties were investigated in male rats. Materials and Methods Four 1, 4-dihydropyr...

[ 3 ] - Antinociceptive Effect of Elaeagnus angustifolia Fruits on Sciatic Nerve Ligated Mice

Objective(s) The role of Elaeagnus angustifolia fruit as an analgesic agent in acute pain has been proved earlier. In this study, the effects of aqueous extracts of three parts of this fruit (pericarp, medulla and seed) on chronic pain were investigated in mice. Materials and Methods A partial nerve injury was made using a tight ligature around the sciatic nerve, then doses (0.5, 1, 1.5 g/kg...

[ 4 ] - Review of the Pharmacological and Toxicological Effects of Salvia leriifolia

Salvia leriifolia Benth. (vernacular names such as Nuruozak and Jobleh) is a perennial herbaceous plant that grows exclusively in south and tropical regions of Khorasan and Semnan provinces, I. R. Iran. Unlike other species of Salvia genus, the chemical constituents of S. leriifolia are not well recognized. The stem oil of the plant consisted mainly both monoterpenes and sesquiterpenes, while i...

[ 5 ] - Evaluation of Antidepressant Effects of Aerial Parts of Echium vulgare on Mice

Objective In traditional medicine, Echium spp., including E. vulgare L., are utilized as exhilarant and mood stimulant. On the other hand, depression is a state of intense sadness, melancholia or despair that has advanced to the point of being disruptive to an individual's social functioning and/or activities of daily living. Therefore, finding effective and safe treatments is a hotly conteste...