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Elahe Taghiabadi

Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

[ 1 ] - Protective effect of thymoquinone, the active constituent of Nigella sativa fixed oil, against ethanol toxicity in rats

Objective(s): Long term consumption of ethanol may induce damage to many organs. Ethanol induces its noxious effects through reactive oxygen species production, and lipid peroxidation and apoptosis induction in different tissues and cell types. Previous experiments have indicated the antioxidant characteristics of thymoquinone, the active constituent of Nigella sativa fixed oil, against biologi...

[ 2 ] - Effect of Nigella sativa fixed oil on ethanol toxicity in rats

Objective(s):This study was planned to appraise the protective effect of Nigella sativa fixed oil (NSO) against subchronic ethanol induced toxicity in rats. Materials and Methods: Studies were carried out on six groups of six animals each, including control (normal saline, gavage), ethanol (3 g/kg/day, gavage), NSO (0.125, 0.25 and 0.5 ml/Kg/day, IP) plus ethanol and NSO (0.5 ml/Kg/day, IP) gro...

[ 3 ] - Antinociceptive Effect of Elaeagnus angustifolia Fruits on Sciatic Nerve Ligated Mice

Objective(s) The role of Elaeagnus angustifolia fruit as an analgesic agent in acute pain has been proved earlier. In this study, the effects of aqueous extracts of three parts of this fruit (pericarp, medulla and seed) on chronic pain were investigated in mice. Materials and Methods A partial nerve injury was made using a tight ligature around the sciatic nerve, then doses (0.5, 1, 1.5 g/kg...

[ 4 ] - Protective Effect of Aqueous and Ethanolic Extracts of Portulaca Oleracea Against Cisplatin Induced Nephrotoxicity

Objective(s) Portulaca oleracea L. is a herbaceous weed from portulacaceae family. It can be found in many parts of the world. Modern pharmacological studies have demonstrated that P. oleracea have antioxidant effects. The protective effect of aqueous and ethanolic extract of P. oleracea against cisplatin-induced renal toxicity was studied in rats. Materials and Methods Single intraperitonea...

[ 5 ] - Effect of crocin, an active saffron constituent, on ethanol toxicity in the rat: histopathological and biochemical studies

<em><strong>Objective(s):</strong></em> The drinking of ethanol causes the wide range of clinical illness and morphological changes including hepatotoxicity and nephrotoxicity. In the current study, the protective properties of crocin versus oxidative stress, apoptosis and inflammation induced by ethanol were assessed. <br /><em><strong>Materials and Methods:</strong> </em>The male Wistar rats ...