Trials of two candidate Ebola vaccines have been fast tracked and will now begin in west Africa in December, the World Health Organization has said. A meeting of officials from the affected countries, donors, manufacturers, funding agencies, and civil society representatives met on 23 October and agreed that clinical trials could begin in December, bringing the trial start date forward a month....

BACKGROUND Maximal aldosterone secretion in healthy dogs occurs 30 minutes postadrenocorticotropin (ACTH; 5 μg/kg IV) stimulation. The effect of trilostane and mitotane on aldosterone at that time is unknown. OBJECTIVES To assess the effect of trilostane and mitotane in dogs with pituitary-dependent hyperadrenocorticism on aldosterone secretory reserve. To determine if aldosterone concentrati...

STUDY OBJECTIVES To explore the acute systemic inflammatory and anabolic effects of cycling in hospital admitted patients with chronic obstructive pulmonary disease (COPD) and in patients with clinically stable disease. DESIGN Cross-sectional comparative study. SETTING University Hospital Gasthuisberg, a tertiary care setting. PATIENTS 16 patients with clinically stable COPD (no acute exa...

The objective of this study was to summarize the incidence of postoperative cognitive dysfunction (POCD) after 7days following liver transplantation (LT), and to evaluate the effectiveness of bispectral index (BIS) guided anesthetic intervention in reducing POCD. Additional serum concentrations of S100β and neuron-specific enolase (NSE) were detected during surgery to determine whether they wer...

introduction: intensive care unit is one of the most stressful wards for patients and it is estimated that 30 to70 percent of patients experience severe physiologic stress during admission. some of the physiologic responses to stress include increase in metabolic rate with consequent increase in body temperature, increase in cardiac output and contraction power and subsequently increase in bloo...

BACKGROUND AND OBJECTIVES Normovolemic hemodilution produces conflicting results on hemostasis, since works differ according to the fluids used, degree of hemodilution, method used to evaluate hemostasis, and the way used to produce hemodilution. The effects of hemodilution on hemostasis can depend on how it is done and whether an in vivo or an in vitro model is used. The objective of this stud...

conclusions the study showed that preparation package was effective in decreasing sbp and dbp, as well as heart rate. therefore, using multimodal comprehensive preparation packages, such as the package used in the present report, is suggested. results from the total number of 66 patients, the 63.3% were male and married. no significant differences were observed between the mean of sbp and dbp a...