Aims: The present study aimed to determine the effect of a long-term cholesterol enriched diet on spatial learning performance in middle to old aged rats. Materials and methods: Based on initial Morris water maze results, 40 female SD rats aged 12-month were screened and randomly divided into 2 groups. Two groups of female SD rats were fed either a balanced diet or a high cholesterol diet for 6...

In this study, the hypothesis that improvements in functional and structural measures could be detected in the young, female rat with only 5 days of moderate treadmill training was tested. Eight-week-old female Sprague-Dawley rats were divided randomly into control (n = 10) and training groups (n = 11). Over the 5-day period, running duration and treadmill speed increased progressively. Maximal...

background: oleuropein is a phenolic compound which is present in the olive leaf extract. the purpose of the present study was to investigate the neuroprotective effect of oleuropein as an antioxidant agent on the substantia nigra in aged rats. methods: twenty 18-month-old wistar rats (450-550 g) were randomly divided into control and experimental groups. the experimental group received a daily...

diabetes mellitus is accompanied with disturbances in learning, memory, and cognitive skills in the human society and experimental animals. therefore, this research study was conducted to evaluate time-dependent changes in passive avoidance and y-maze performance in male diabetic rats. for this purpose, male wistar rats were randomly divided into control and diabetic groups. for induction of di...

Background. SIRT3 is one of the members of the Sirtuin deacetylase protein family which is linked to the longevity of human being and is used as an important therapeutic and diagnostic marker in illness and aging. Objectives. The aim of this study was studying the effect of continuous swimming training on some biomarkers of longevity in slowtwitch (SOL) and fast-twitch (EDL) muscles of adult m...

A total of 300 one-day old male broilers (Cobb 500) were randomly divided into four treatment groups. The groups comprised of 15 birds each, and were defined by diet and the birds in each group were fed 0 (control), 3, 5, or 7 kGy electron-beam irradiated diets. A total of 5 replicates were performed. The chemical composition of the diet was not affected by irradiation.Irradiation doses of 5 an...

background: margarine contain trans fatty acids as major sources of dietary free radicals, and oxidative stress. effect of oral administration of margarine on hepatic enzyme was investigated in wistar rats. methods: thirty six (36) adult wistar rats were uniformly divided into three groups of control , margarine 15% and 20%, twelve rats in each groups (6males & 6 females). margarine was added t...

this study aims to investigate the effect of xylopia aethiopica on the sexual behavior of adult male rats. fort eight adult male wistar rats were used for the study. they were randomly divided into four groups of 6 animals each: group 1 was control, while groups 2, 3 and 4 were test groups treated daily with 0.5, 2 and 10 mg/kg body weight respectively of hydro-methanolic fruit extract of xylop...