Aim: To investigate near infrared-induced phototoxicity toward lung cancer cells, and the biodegradability effect on immune cells of glucose-derived carbon nanoparticles (CNPs). Methods: The human A549 adenocarcinoma cell line was used as a model to study CNPs. demonstrated in primary neutrophils macrophages. Results: Near infrared-activated CNPs elicited rapid death, characterized by elevation...

TRIM27 belongs to the family of tripartite motif (TRIM)-containing proteins. Alterative in TRIM proteins have been implicated in several malignancies. The aim of this study was to evaluate the significance of TRIM27 expression in patients with lung cancer and to define its exact role in human lung cancer proliferation, adhesion, invasion and migration. Here, TRIM27 expression was higher in lung...

Emerging evidence has demonstrated that microRNAs (miRNA) play a critical role in chemotherapy-induced epithelial-mesenchymal transition (EMT) in lung cancer. However, the underlying mechanism of chemotherapy-mediated EMT has not been fully elucidated. In the present study, we explored the role of miR-103 in regulating cisplatin (DDP)-mediated EMT in human lung adenocarcinoma A549/DDP cells. Re...

BACKGROUND Lung cancer is one of the most frequently diagnosed malignancies in the world, thus developing novel anticancer reagents for lung cancer treatment is critical. METHODS We performed cell counting kit-8 and cell colony formation assays to investigate the role of UNBS5162 in the proliferation of A549 cells. Invasion and migration assays were applied to study the inhibitory effect of U...

The aim of this study was to investigate the role of apelin in the cell proliferation and autophagy of lung adenocarcinoma. The over-expression of APJ in lung adenocarcinoma was detected by immunohistochemistry, while plasma apelin level in lung cancer patients was measured by enzyme-linked immunosorbent assay. Our findings revealed that apelin-13 significantly increased the phosphorylation of ...

Metformin (Met) has been widely used in hypoglycemic therapy, and it is also able to reduce the incidence of tumors and tumor-related mortality. The present study investigated whether Met could inhibit the proliferation of lung cancer cells and enhance the sensitivity of a cisplatin-resistant lung cancer A549/CDDP cell line to cisplatin. It was found that Met treatment inhibited the proliferati...

Objective: The aim of the study was to improve the therapeutic effect for lung cancer using a synergetic strategy of adenovirus-based gene therapy combined with chemotherapy. Methods: A conditional replication adenovirus(CRAd) was employed to treat the A549 lung cancer cells and cisplatin-resisted A549(A549-DDP) cells. In vitro MTS / PMS assay were used to evaluate the cell viability. PCR were ...

BACKGROUND Evodiamine, a compound isolated from the Evodia rutaecarpa Bentham (Rutaceae), is known to have a potential anti-proliferative activity in human cancer cells. However, the growth inhibitory activity against lung cancer cells and the underlying molecular mechanisms have been poorly determined. The present study was designed to examine the anti-proliferative effect of evodiamine in A54...

Pellino-1 is an E3 ubiquitin ligase that mediates immune receptor signaling pathways. The role of Pellino-1 in oncogenesis of lung cancer was investigated in this study. Pellino-1 expression was increased in human lung cancer cell lines compared with non-neoplastic lung cell lines. Pellino-1 overexpression in human lung cancer cells, A549 and H1299 cells, increased the survival and colony formi...