نتایج جستجو برای: advanced parkinson disease
تعداد نتایج: 1703547 فیلتر نتایج به سال:
Thiazolidinediones, a class of medications indicated for the treatment of type 2 diabetes mellitus, reduce inflammation and have been shown to provide a therapeutic benefit in animal models of Parkinson disease. We examined the association between treatment with thiazolidinediones and the onset of Parkinson disease in older individuals. We performed a cohort study of 29,397 Medicare patients en...
Diffusion tensor tractography was used to evaluate whether diffusion metrics in the nigrostriatal pathway could diagnose Parkinson disease. Diffusion tensor imaging was performed on 30 patients with Parkinson disease and 32 healthy controls by using a 3.0 Tesla magnetic resonance imaging system. Diffusion tensor tractography was used for both groups to visualize the nigrostriatal and corticospi...
BACKGROUND Parkinson disease frequently causes difficulty turning that can lead to falls, loss of independence, and diminished quality of life. Turning in tight spaces, which may be particularly impaired in Parkinson disease, is an essential part of our daily lives, yet a comprehensive analysis of in-place turning has not been published. OBJECTIVE This study was conducted to determine whether...
Increased somatic mitochondrial DNA (mtDNA) mutagenesis causes premature aging in mice, and mtDNA damage accumulates in the human brain with aging and neurodegenerative disorders such as Parkinson disease (PD). Here, we study the complete spectrum of mtDNA changes, including deletions, copy-number variation and point mutations, in single neurons from the dopaminergic substantia nigra and other ...
Committee of the European Academy of Neurology in Brussels, Belgien. He is also a member of the high level advisory board for the European Ministry for Research and Development " Scientific Panel for Health (SPH) ". He has received many prestigious awards during his career, including the " carrier award for basal ganglia disorders " On the International Conference: Clinical Update Sleep 2016, w...
BACKGROUND Mutations in the PTEN-induced kinase (PINK1) gene located within the PARK6 locus on chromosome 1p35-p36 have recently been identified in patients with recessive early-onset Parkinson disease. OBJECTIVE To assess the prevalence of PINK1 mutations within a series of early- and late-onset Parkinson disease patients living in North America. DESIGN All coding exons of the PINK1 gene w...
Mutations in alpha-synuclein gene cause familial form of Parkinson disease, and deposition of wild-type alpha-synuclein as Lewy bodies occurs as a hallmark lesion of sporadic Parkinson disease and dementia with Lewy bodies, implicating alpha-synuclein in the pathogenesis of Parkinson disease and related neurodegenerative diseases. Dopamine neurons in substantia nigra are the major site of neuro...
Artificial neural network(ANN) with tansig, logsig and purelin transfer function, support vector machines(SVM), linear and quadratic classifiers are used in this work for the detection of Parkinson disease using voice features. In the Parkinson disease, voice of a person changes because of presence of tremor in the voicebox muscles. Total 195 phonations were used for the analysis from twenty th...
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