Background Ageing has become a serious challenge in Hong Kong and globally. It has serious implications for health expenditure, which accounts for nearly 20% of overall government expenditure. Here we assess the contribution of ageing and related factors to hospitalisation days in Hong Kong. We used hospital discharge data from all publicly funded hospitals in Hong Kong between 2001 and 2012.  ...

Until recently the biology of ageing, like that of consciousness, seemed an unassailable topic. Ageing was to biologists an intractable labyrinth of diverse deteriorative processes within which primary causes were impossible to locate. But around 15 years ago, discoveries in the genetics of ageing initiated a startling forward march in biogerontology (the study of the biology of ageing). In par...

A decline in the main sensory modalities is well reported to occur with ageing. This article outlines the normal pathways involved in touch sensation and includes a review of available evidence relating to the study of ageing and touch. The authors try to use what is known about the neuroanatomy and neurophysiology of ageing to explain the impact on some broad functional deficits seen in the el...

1. Abstract 2. Introduction 3. Structure and Functions of Choroid Plexus 3.1. Structure of choroid plexus 3.2. Functions of choroid plexus 3.3. Composition of cerebrospinal fluid 4. Ageing of Choroid Plexus 4.1. Anatomical modifications in ageing 4.2. Functional alterations in ageing 4.3. Modification of cerebrospinal fluid in ageing 5. Choroid Plexus and Alzheimer’s Disease 5.1. Anatomical alt...

Room temperature ‘natural’ ageing in Al-Mg-Si alloys was studied by means of six different techniques: electrical resistivity, thermoanalysis, hardness measurement, lifetime of positrons, 3D atom probe and small-angle neutron scattering in order to identify different clustering stages and to study when the negative effect of natural ageing on subsequent ‘artificial’ ageing sets in. The various ...

The age hardening process of a 6082 Al–Mg–Si alloy by isothermal ageing at 100, 125 and 150 °C for 0 to 40 days has been investigated by both conventional and high-resolution transmission electron microscopy. Changes in sizes and densities of the pre-β and β phases during ageing can explain the evolution of hardness, in particular a plateau in the curve of the hardness versus ageing time. Fully...

Brangus steers (n=247) finished on pasture were used to evaluate the effects of post-mortem ageing and polymorphism CAPN1 316 and CAPN1 4751 markers on meat tenderness and objective colour measurements (CIEL*a*b*) of m. Longissimus dorsi. Ageing meat for 7 days decreased shear force (SF) by 13.7% and improved a* (8.4%) and b* (10%) compared to ageing for 1 day. No difference between 7 and 14 da...

Abstract In the mid-1970s the first studies, in the form of inspections of building joints, were conducted in England and Germany into the failure rate of sealants. As a consequence of these studies, the ageing behaviour of sealants was investigated with the aid of artificial accelerated ageing methods and by storing sealants outdoors for several years in moderate or tropical climates. The resu...

DNA damage has been implicated in ageing, but direct evidence for a causal relationship is lacking, owing to the difficulty of inducing defined DNA lesions in cells and tissues without simultaneously damaging other biomolecules and cellular structures. Here we directly test whether highly toxic DNA double-strand breaks (DSBs) alone can drive an ageing phenotype using an adenovirus-based system ...

Increases in human lifespan worldwide have revealed that advancing age is the predominant risk factor for major life-threatening diseases. Recent work has shown that ageing in diverse animals, including humans, is malleable to specific types of genetic mutation, diet, and drugs that can extend lifespan and improve health during ageing. These findings point to the prospect of broad-spectrum prev...