In studies of the interactions of antibacterial agents, it became important to try to elicit bacterial resistance to antibiotics in the experimental animal. Since this proved to be unexpectedly difficult, attention was directed to the process by which bacteria acquire resistance during exposure in vivo. The present paper is concerned with the incidence of streptomycin resistance in strains of s...

Various herbs are used as analgesic, anti-inflammatory, anti-bacterial, anti-fungal, expectorant, anti-plaque and odorant. Sentul is an edible fruit also in traditional medicinal which can treat diarrhea, relieve fever, anthelmintic. bark methanol extract inhibit the growth of fungus Candida albican by 39.65%. In addition, ethyl acetate sentul leaves has anti-bacterial activity. The aim this st...

BACKGROUND AND OBJECTIVES Bacterial resistance to antibiotics has motivated the researchers to evaluate the novel anti-bacterial compounds such as some thiazole and imidazole derivatives. Thereby, in this work, we investigated the anti-bacterial effects of one new thiazole and two new imidazole derivatives on Bacillus cereus, Listeria monocytogenes, Escherichia coli, Salmonella typhimurium, Pro...

Drug resistance in fecal bacteria was high in Wayampis Amerindians who did not take antibacterial agents and were not hospitalized for 1 year. In the Wayampis Amerindians, an isolated traditional community in French Guyana, antibacterial use was 0.64 treatments per person per year. Hospitalization rate was 6.1% per year. Antibacterial drug-resistant bacteria can spread in persons who are not ta...

A novel series of 8-amino imidazo[1,2-a]pyrazine derivatives has been developed as inhibitors of the VirB11 ATPase HP0525, a key component of the bacterial type IV secretion system. A flexible synthetic route to both 2- and 3-aryl substituted regioisomers has been developed. The resulting series of imidazo[1,2-a]pyrazines has been used to probe the structure-activity relationships of these inhi...

BACKGROUND The aim of this study was to evaluate the effect of an anti-flagellin sub-type monoclonal antibody (anti-fla-a) on Pseudomonas aeruginosa infection in a mouse burn model and to assay bacterial dissemination and invasiveness. METHODS After immediate post-burn infection with P. aeruginosa, mortality and morbidity (daily weight changes) were monitored in mice treated with anti-fla-a a...

Background: Recently the role of platelets in the tissue regeneration, wound healing and prevention and control of infections has been reported. We aimed to assess the antimicrobial effect of human platelet concentrate against six bacteria, commonly found in wound and hospital-acquired infections. Methods: In vitro susceptibility to samples of 10 random human platelet concentrates was determin...

Glycyrrhiza glabra L. (family-Fabaceae-Leguminosae) is one of the important medicinal plant, commonly called as ‘liquorice’. The main ingredient of liquorice is ‘glycyrrhizin’. The present experiment was focused on the anti-inflammatory activity of hydro alcoholic extract of G. glabra (HAEGG) root against carrageenan induced rat paw oedema at dose levels of 100, 200, and 300 mg/kg orally. The H...