Abstract Cervical cancer is a typical characterized by abnormal cell growth in the cervical area. Ginkgo biloba L. deciduous tree of genus , possessing anti-cancer effects. The aim this study was to explore effect strain J1 from on apoptosis cells. Bacteriostatic activity test, MTT assay and Flow cytometry were used study. Crude extract fermentation reduced cancer. crude broth had good inhibito...

Introduction and Aim: The metabolic oxidative stress induces highly reactive free radicals that are known to harm normal physiology play a role in the development of cancer. Elevated levels these contribute excessive neovascularization leading angiogenesis mediated cancer progression. Targeting through dietary source is important strategy regulation Allium sativum L. (AsL) garlic has multi phar...

dna intercalators belong to aromatic heterocyclic compounds interacting reversibly with dna. these compounds have been used extremely as cytotoxic agents against cancer. in this study, the synthesis and biological activity of some novel derivatives of cyclopenta [b] quinoline-1, 8-dione as new intercalating agent were investigated. twenty novel derivatives of cyclopenta [b] quinoline-1, 8-dione...

Background: Nisin, an effective natural food preservative, is an antimicrobial peptide produced by Lactococcus lactis. Although it has been mainly studied and developed as a potential alternative for antibiotics, other pharmacological effects of the nisin including cytotoxic and anti-tumor activity have been attracted many attentions.Objectives: Here, we ...

Objective(s): Glioblastoma multiforme (GBM) is one of the most lethal forms of human cancer and temozolomide (TMZ) is currently part of the standard treatment for this disease. Combination therapy using natural substances can enhance the anti-cancer activity of TMZ. The purpose of this study was to evaluate the effect of TMZ in combination with thymoquinone (TQ) on human GBM cell line (U87MG). ...

In present study novel series of benzothiazole derivatives were synthesized and their anti cancer efficacy was analyzed using cancer cell lines (Human Chronic Myelogenous Leukemia). The compounds were synthesized by simple and facile procedures and characterized by IR, H-NMR and Mass spectra study. The synthesized compounds were screened for anti cancer activity using in vitro assays. The compo...

Cancer-associated fibroblasts (CAFs) are highly abundant stromal components in the tumour microenvironment. These cells contribute to tumorigenesis and indeed, they have been proposed as a target for anti-cancer therapies. Similarly, targeting Rho-GTPase RAC1 has also suggested potential therapeutic cancer. Here, we show that activity, either pharmacologically or by genetic silencing, increases...